Gene description for Rbbp7
Gene name retinoblastoma binding protein 7
Gene symbol Rbbp7
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Rbbp7
ExoCarta ExoCarta_83712
Entrez Gene 83712
UniProt Q71UF4  
 Rbbp7 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Rbbp7
Molecular Function
    RNA binding GO:0003723 ISO
    molecular_function GO:0003674 ND
Biological Process
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    negative regulation of cell growth GO:0030308 ISS
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    response to steroid hormone GO:0048545 IEP
    chromatin modification GO:0016568 IEA
    cellular heat acclimation GO:0070370 ISS
    DNA replication GO:0006260 IEA
Subcellular Localization
    ESC/E(Z) complex GO:0035098 ISS
    NuRD complex GO:0016581 ISS
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Rbbp7 in exosomes
1
Experiment ID 96
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Rbbp7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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