Gene description for Fbn1
Gene name fibrillin 1
Gene symbol Fbn1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Fbn1
ExoCarta ExoCarta_83727
Vesiclepedia VP_83727
Entrez Gene 83727
 Fbn1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Fbn1
Molecular Function
    integrin binding GO:0005178 ISO
    hormone activity GO:0005179 ISO
    extracellular matrix structural constituent GO:0005201 IBA
    extracellular matrix structural constituent GO:0005201 ISO
    calcium ion binding GO:0005509 ISO
    heparin binding GO:0008201 ISO
    identical protein binding GO:0042802 ISO
    protein-containing complex binding GO:0044877 ISO
Biological Process
    skeletal system development GO:0001501 ISO
    metanephros development GO:0001656 IMP
    kidney development GO:0001822 IEP
    kidney development GO:0001822 IMP
    glucose metabolic process GO:0006006 ISO
    signal transduction GO:0007165 IEA
    heart development GO:0007507 ISO
    anatomical structure morphogenesis GO:0009653 IBA
    gene expression GO:0010467 ISO
    protein kinase A signaling GO:0010737 ISO
    lung development GO:0030324 ISO
    positive regulation of appetite GO:0032100 ISO
    cell adhesion mediated by integrin GO:0033627 ISO
    activation of protein kinase A activity GO:0034199 ISO
    sequestering of BMP in extracellular matrix GO:0035582 ISO
    sequestering of TGFbeta in extracellular matrix GO:0035583 ISO
    glucose homeostasis GO:0042593 ISO
    camera-type eye development GO:0043010 ISO
    negative regulation of osteoclast differentiation GO:0045671 ISO
    negative regulation of insulin secretion GO:0046676 ISO
    embryonic eye morphogenesis GO:0048048 ISO
    post-embryonic eye morphogenesis GO:0048050 ISO
    lung alveolus development GO:0048286 ISO
    cellular response to transforming growth factor beta stimulus GO:0071560 IEP
    negative regulation of brown fat cell differentiation GO:1903444 ISO
    cellular response to insulin-like growth factor stimulus GO:1990314 IEP
    negative regulation of osteoclast development GO:2001205 ISO
Subcellular Localization
    microfibril GO:0001527 ISO
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 ISO
    basement membrane GO:0005604 ISO
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISO
    extracellular matrix GO:0031012 IBA
    extracellular matrix GO:0031012 ISO
    collagen-containing extracellular matrix GO:0062023 IDA
    collagen-containing extracellular matrix GO:0062023 ISO
 Experiment description of studies that identified Fbn1 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Fbn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fbn1 is involved
No pathways found





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