Gene description for Fbn1
Gene name fibrillin 1
Gene symbol Fbn1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Fbn1
ExoCarta ExoCarta_83727
Entrez Gene 83727
 Fbn1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Fbn1
Molecular Function
    calcium ion binding GO:0005509 ISO
    integrin binding GO:0005178 ISO
    protein complex binding GO:0032403 ISO
    extracellular matrix structural constituent GO:0005201 ISO
Biological Process
    heart development GO:0007507 ISO
    sequestering of BMP in extracellular matrix GO:0035582 ISO
    cellular response to transforming growth factor beta stimulus GO:0071560 IEP
    regulation of cellular response to growth factor stimulus GO:0090287 IBA
    cellular response to insulin-like growth factor stimulus GO:1990314 IEP
    anatomical structure morphogenesis GO:0009653 IBA
    sequestering of TGFbeta in extracellular matrix GO:0035583 ISO
    kidney development GO:0001822 IMP
    skeletal system development GO:0001501 ISO
    metanephros development GO:0001656 IMP
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 ISO
    proteinaceous extracellular matrix GO:0005578 ISO
    basement membrane GO:0005604 ISO
    microfibril GO:0001527 ISO
    extracellular region GO:0005576 ISO
    extracellular matrix GO:0031012 ISO
 Experiment description of studies that identified Fbn1 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Fbn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fbn1 is involved
No pathways found





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