Gene description for Rtn4
Gene name reticulon 4
Gene symbol Rtn4
Other names/aliases NI-250
Nogo
Nogo-A
Vp20
r
rat N
rat NogoA
Species Rattus norvegicus
 Database cross references - Rtn4
ExoCarta ExoCarta_83765
Vesiclepedia VP_83765
Entrez Gene 83765
UniProt Q9JK11  
 Rtn4 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Rtn4
Molecular Function
    poly(A) RNA binding GO:0044822 ISO
    protein binding GO:0005515 IPI
    protein complex binding GO:0032403 IDA
Biological Process
    negative regulation of cell growth GO:0030308 ISO
    negative regulation of axon extension GO:0030517 ISS
    cerebral cortex radial glia guided migration GO:0021801 ISS
    response to activity GO:0014823 IEP
    positive regulation of glial cell differentiation GO:0045687 IDA
    nervous system development GO:0007399 ISO
    regulation of cell migration GO:0030334 ISO
    axonal fasciculation GO:0007413 ISO
    regulation of nervous system development GO:0051960 ISO
    negative regulation of neuron projection development GO:0010977 IDA
    negative regulation of neuron projection regeneration GO:0070571 IMP
    cardiac epithelial to mesenchymal transition GO:0060317 ISO
    negative regulation of neuron differentiation GO:0045665 IDA
    positive regulation of dopamine secretion GO:0033603 IMP
    regulation of sensory perception of pain GO:0051930 IDA
    negative regulation of axonogenesis GO:0050771 IMP
    regulation of branching morphogenesis of a nerve GO:2000172 ISO
    oligodendrocyte differentiation GO:0048709 IEP
    angiogenesis GO:0001525 ISO
    axonogenesis GO:0007409 IBA
    endoplasmic reticulum tubular network organization GO:0071786 ISO
    olfactory nerve development GO:0021553 IEP
    aging GO:0007568 IEP
Subcellular Localization
    cell projection GO:0042995 ISO
    neuron projection GO:0043005 IDA
    neuronal postsynaptic density GO:0097481 ISO
    integral component of membrane GO:0016021 TAS
    extracellular exosome GO:0070062 ISO
    plasma membrane GO:0005886 IDA
    integral component of endoplasmic reticulum membrane GO:0030176 ISO
    cytoplasm GO:0005737 IDA
    protein complex GO:0043234 IDA
    neuronal cell body GO:0043025 ISO
    myelin sheath GO:0043209 IDA
    endoplasmic reticulum GO:0005783 ISO
    endomembrane system GO:0012505 IBA
    intracellular GO:0005622 ISO
    nuclear envelope GO:0005635 ISS
 Experiment description of studies that identified Rtn4 in exosomes
1
Experiment ID 225
MISEV standards
EM
EV Biophysical techniques
GAPDH|CD63
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Rtn4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rtn4 is involved
PathwayEvidenceSource
Axonal growth inhibition (RHOA activation) IEA Reactome





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