Gene description for Lgals3
Gene name	lectin, galactoside-binding, soluble, 3
Gene symbol	Lgals3
Other names/aliases	AGE-R3 CBP30 L-34 gal-3
Species	Rattus norvegicus
Database cross references - Lgals3
ExoCarta	ExoCarta_83781
Vesiclepedia	VP_83781
Entrez Gene	83781
UniProt	P08699
Lgals3 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Lgals3

Molecular Function     protein phosphatase inhibitor activity GO:0004864 IEA     protein phosphatase inhibitor activity GO:0004864 ISO     IgE binding GO:0019863 IBA     IgE binding GO:0019863 IDA     IgE binding GO:0019863 IEA     IgE binding GO:0019863 ISO     protein phosphatase binding GO:0019903 IEA     protein phosphatase binding GO:0019903 ISO     carbohydrate binding GO:0030246 IEA     carbohydrate binding GO:0030246 ISO     signaling receptor inhibitor activity GO:0030547 IEA     signaling receptor inhibitor activity GO:0030547 ISO     Fc-gamma receptor I complex binding GO:0034988 IDA     chemoattractant activity GO:0042056 IEA     chemoattractant activity GO:0042056 ISO     laminin binding GO:0043236 IBA     laminin binding GO:0043236 IEA     laminin binding GO:0043236 ISO     monosaccharide binding GO:0048029 IDA     disaccharide binding GO:0048030 IBA     disaccharide binding GO:0048030 IDA     advanced glycation end-product receptor activity GO:0050785 IDA     oligosaccharide binding GO:0070492 ISO     molecular condensate scaffold activity GO:0140693 IEA     molecular condensate scaffold activity GO:0140693 ISO     receptor ligand inhibitor activity GO:0141069 IEA     receptor ligand inhibitor activity GO:0141069 ISO Biological Process     skeletal system development GO:0001501 ISO     monocyte chemotaxis GO:0002548 IBA     monocyte chemotaxis GO:0002548 IEA     monocyte chemotaxis GO:0002548 ISO     mRNA processing GO:0006397 IEA     positive regulation of cell population proliferation GO:0008284 IMP     RNA splicing GO:0008380 IEA     positive regulation of serotonin secretion GO:0014064 IDA     cell differentiation GO:0030154 IEA     extracellular matrix organization GO:0030198 ISO     neutrophil chemotaxis GO:0030593 IBA     neutrophil chemotaxis GO:0030593 IEA     neutrophil chemotaxis GO:0030593 ISO     epithelial cell differentiation GO:0030855 IEA     epithelial cell differentiation GO:0030855 ISO     positive regulation of protein-containing complex assembly GO:0031334 IEA     positive regulation of protein-containing complex assembly GO:0031334 ISO     regulation of T cell proliferation GO:0042129 IEA     regulation of T cell proliferation GO:0042129 ISO     negative regulation of apoptotic process GO:0043066 IDA     innate immune response GO:0045087 IEA     maintenance of protein location GO:0045185 ISO     positive regulation of angiogenesis GO:0045766 IMP     negative regulation of endocytosis GO:0045806 IBA     negative regulation of endocytosis GO:0045806 IEA     negative regulation of endocytosis GO:0045806 ISO     eosinophil chemotaxis GO:0048245 IBA     eosinophil chemotaxis GO:0048245 IEA     eosinophil chemotaxis GO:0048245 ISO     macrophage chemotaxis GO:0048246 IBA     macrophage chemotaxis GO:0048246 IEA     macrophage chemotaxis GO:0048246 ISO     negative regulation of T cell receptor signaling pathway GO:0050860 ISO     positive chemotaxis GO:0050918 IBA     positive chemotaxis GO:0050918 IEA     positive chemotaxis GO:0050918 ISO     negative regulation of NK T cell activation GO:0051134 IEA     negative regulation of NK T cell activation GO:0051134 ISO     antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 ISO     regulation of T cell apoptotic process GO:0070232 IEA     regulation of T cell apoptotic process GO:0070232 ISO     mononuclear cell migration GO:0071674 ISO     positive regulation of mononuclear cell migration GO:0071677 IEA     positive regulation of mononuclear cell migration GO:0071677 ISO     positive regulation of calcium ion import GO:0090280 IBA     positive regulation of calcium ion import GO:0090280 IEA     positive regulation of calcium ion import GO:0090280 ISO     regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 IEA     regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 ISO     positive regulation of protein localization to plasma membrane GO:1903078 IEA     positive regulation of protein localization to plasma membrane GO:1903078 ISO     negative regulation of cell proliferation in bone marrow GO:1903769 IDA     response to quercetin GO:1905235 IEP     negative regulation of immunological synapse formation GO:2000521 ISO     negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001189 ISO     positive regulation of dendritic cell differentiation GO:2001200 ISO     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IBA     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IEA     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO Subcellular Localization     cornified envelope GO:0001533 ISO     immunological synapse GO:0001772 IBA     immunological synapse GO:0001772 IEA     immunological synapse GO:0001772 ISO     extracellular region GO:0005576 IEA     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 IEA     extracellular space GO:0005615 ISO     nucleus GO:0005634 IBA     nucleus GO:0005634 ISO     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     spliceosomal complex GO:0005681 IEA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     mitochondrial inner membrane GO:0005743 IEA     mitochondrial inner membrane GO:0005743 ISO     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     plasma membrane GO:0005886 TAS     external side of plasma membrane GO:0009897 ISO     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     extracellular matrix GO:0031012 ISO     glial cell projection GO:0097386 ISO