Gene description for Tnk1
Gene name tyrosine kinase, non-receptor, 1
Gene symbol Tnk1
Other names/aliases Kos1
Tnk1a
Tnk1b
Species Mus musculus
 Database cross references - Tnk1
ExoCarta ExoCarta_83813
Vesiclepedia VP_83813
Entrez Gene 83813
UniProt Q99ML2  
 Tnk1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tnk1
Molecular Function
    protein tyrosine kinase activity GO:0004713 IBA
    protein tyrosine kinase activity GO:0004713 ISO
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    ATP binding GO:0005524 IMP
    ATP binding GO:0005524 ISO
    histone H3Y41 kinase activity GO:0035401 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    negative regulation of cell growth GO:0030308 IMP
    negative regulation of Ras protein signal transduction GO:0046580 IMP
    protein autophosphorylation GO:0046777 IDA
    protein autophosphorylation GO:0046777 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IBA
    membrane GO:0016020 IEA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Tnk1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tnk1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tnk1 is involved
No pathways found





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