Gene description for Tnk1
Gene name tyrosine kinase, non-receptor, 1
Gene symbol Tnk1
Other names/aliases Kos1
Tnk1a
Tnk1b
Species Mus musculus
 Database cross references - Tnk1
ExoCarta ExoCarta_83813
Entrez Gene 83813
UniProt Q99ML2  
 Tnk1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tnk1
Molecular Function
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    transferase activity GO:0016740 IEA
    protein tyrosine kinase activity GO:0004713 ISO
    kinase activity GO:0016301 IEA
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 ISO
    hormone receptor binding GO:0051427 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    protein kinase activity GO:0004672 IEA
Biological Process
    protein autophosphorylation GO:0046777 ISO
    peptidyl-tyrosine phosphorylation GO:0018108 ISO
    cell migration GO:0016477 IBA
    protein phosphorylation GO:0006468 IEA
    peptidyl-tyrosine autophosphorylation GO:0038083 IBA
    innate immune response GO:0045087 IBA
    negative regulation of Ras protein signal transduction GO:0046580 IMP
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    phosphorylation GO:0016310 IEA
    negative regulation of cell growth GO:0030308 IMP
    cell differentiation GO:0030154 IBA
    regulation of cell proliferation GO:0042127 IBA
Subcellular Localization
    membrane GO:0016020 ISO
    cytosol GO:0005829 IDA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Tnk1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tnk1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tnk1 is involved
No pathways found





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