Gene description for KCTD10
Gene name potassium channel tetramerization domain containing 10
Gene symbol KCTD10
Other names/aliases BTBD28
Species Homo sapiens
 Database cross references - KCTD10
ExoCarta ExoCarta_83892
Entrez Gene 83892
HGNC 23236
MIM 613421
UniProt Q9H3F6  
 KCTD10 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for KCTD10
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 ISS
Biological Process
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    protein ubiquitination GO:0016567 ISS
    protein homooligomerization GO:0051260 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    TCTN-B9D complex GO:0036038 IEA
    Cul3-RING ubiquitin ligase complex GO:0031463 ISS
 Experiment description of studies that identified KCTD10 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for KCTD10
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which KCTD10 is involved
No pathways found

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