Gene description for IMMP2L
Gene name IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
Gene symbol IMMP2L
Other names/aliases IMMP2L-IT1
IMP2
IMP2-LIKE
Species Homo sapiens
 Database cross references - IMMP2L
ExoCarta ExoCarta_83943
Vesiclepedia VP_83943
Entrez Gene 83943
HGNC 14598
MIM 605977
UniProt Q96T52  
 IMMP2L identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for IMMP2L
Molecular Function
    endopeptidase activity GO:0004175 IBA
    serine-type endopeptidase activity GO:0004252 IEA
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 ISS
Biological Process
    ovarian follicle development GO:0001541 IEA
    signal peptide processing GO:0006465 NAS
    protein processing involved in protein targeting to mitochondrion GO:0006627 IBA
    protein processing involved in protein targeting to mitochondrion GO:0006627 ISS
    superoxide metabolic process GO:0006801 IEA
    DNA damage response GO:0006974 IEA
    spermatogenesis GO:0007283 IEA
    brain development GO:0007420 IEA
    blood circulation GO:0008015 IEA
    respiratory electron transport chain GO:0022904 IEA
    ovulation GO:0030728 IEA
    mitochondrial respiratory chain complex assembly GO:0033108 IEA
    cerebellum vasculature development GO:0061300 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane peptidase complex GO:0042720 IBA
    mitochondrial inner membrane peptidase complex GO:0042720 ISS
    mitochondrial inner membrane peptidase complex GO:0042720 NAS
 Experiment description of studies that identified IMMP2L in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for IMMP2L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPD 3184
Two-hybrid Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 CA14 23632
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IMMP2L is involved
No pathways found





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