Gene description for IMMP2L
Gene name IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
Gene symbol IMMP2L
Other names/aliases IMMP2L-IT1
IMP2
IMP2-LIKE
Species Homo sapiens
 Database cross references - IMMP2L
ExoCarta ExoCarta_83943
Vesiclepedia VP_83943
Entrez Gene 83943
HGNC 14598
MIM 605977
UniProt Q96T52  
 IMMP2L identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for IMMP2L
Molecular Function
    endopeptidase activity GO:0004175 IBA
    serine-type endopeptidase activity GO:0004252 IEA
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 ISS
Biological Process
    ovarian follicle development GO:0001541 IEA
    signal peptide processing GO:0006465 NAS
    protein processing involved in protein targeting to mitochondrion GO:0006627 IBA
    protein processing involved in protein targeting to mitochondrion GO:0006627 ISS
    superoxide metabolic process GO:0006801 IEA
    DNA damage response GO:0006974 IEA
    spermatogenesis GO:0007283 IEA
    brain development GO:0007420 IEA
    blood circulation GO:0008015 IEA
    respiratory electron transport chain GO:0022904 IEA
    ovulation GO:0030728 IEA
    mitochondrial respiratory chain complex assembly GO:0033108 IEA
    cerebellum vasculature development GO:0061300 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane peptidase complex GO:0042720 IBA
    mitochondrial inner membrane peptidase complex GO:0042720 ISS
    mitochondrial inner membrane peptidase complex GO:0042720 NAS
 Experiment description of studies that identified IMMP2L in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for IMMP2L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 GLRX5 51218
Proximity Label-MS Homo sapiens
3 AFG3L2 10939
Proximity Label-MS Homo sapiens
4 SLIRP 81892
Proximity Label-MS Homo sapiens
5 NDUFS1 4719
Proximity Label-MS Homo sapiens
6 COX15 1355
Proximity Label-MS Homo sapiens
7 MTPAP 55149
Proximity Label-MS Homo sapiens
8 PYCR1 5831
Proximity Label-MS Homo sapiens
9 IMMP1L  
Proximity Label-MS Homo sapiens
10 MARC2 54996
Proximity Label-MS Homo sapiens
11 NDUFS2 4720
Proximity Label-MS Homo sapiens
12 LRPPRC 10128
Proximity Label-MS Homo sapiens
13 RNH1 6050
Proximity Label-MS Homo sapiens
14 NDUFS3 4722
Proximity Label-MS Homo sapiens
15 TFAM 7019
Proximity Label-MS Homo sapiens
16 DCXR 51181
Proximity Label-MS Homo sapiens
17 IARS2 55699
Proximity Label-MS Homo sapiens
18 HINT2 84681
Proximity Label-MS Homo sapiens
19 PTPMT1 114971
Proximity Label-MS Homo sapiens
20 NDUFA2 4695
Proximity Label-MS Homo sapiens
21 HARS2 23438
Proximity Label-MS Homo sapiens
22 SUPV3L1 6832
Proximity Label-MS Homo sapiens
23 NDUFA5 4698
Proximity Label-MS Homo sapiens
24 MRPS24 64951
Proximity Label-MS Homo sapiens
25 MRPL21 219927
Proximity Label-MS Homo sapiens
26 MRPS26 64949
Proximity Label-MS Homo sapiens
27 POLRMT 5442
Proximity Label-MS Homo sapiens
28 SPDEF  
Proximity Label-MS Homo sapiens
29 LACTB 114294
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
30 NDUFV1 4723
Proximity Label-MS Homo sapiens
31 NDUFV3 4731
Proximity Label-MS Homo sapiens
32 MRPS7 51081
Proximity Label-MS Homo sapiens
33 SLC30A9 10463
Proximity Label-MS Homo sapiens
34 CA14 23632
Affinity Capture-MS Homo sapiens
35 PREPL 9581
Proximity Label-MS Homo sapiens
36 CPOX 1371
Proximity Label-MS Homo sapiens
37 CBR1 873
Proximity Label-MS Homo sapiens
38 MDH2 4191
Proximity Label-MS Homo sapiens
39 MRPS25 64432
Proximity Label-MS Homo sapiens
40 NDUFS4 4724
Proximity Label-MS Homo sapiens
41 SAMM50 25813
Proximity Label-MS Homo sapiens
42 MRPL45 84311
Proximity Label-MS Homo sapiens
43 CHCHD3 54927
Proximity Label-MS Homo sapiens
44 NDUFA8 4702
Proximity Label-MS Homo sapiens
45 MICU2 221154
Proximity Label-MS Homo sapiens
46 MTX2 10651
Proximity Label-MS Homo sapiens
47 PTCD3 55037
Proximity Label-MS Homo sapiens
48 MMAB 326625
Proximity Label-MS Homo sapiens
49 OPA1 4976
Proximity Label-MS Homo sapiens
50 RAP1A 5906
Proximity Label-MS Homo sapiens
51 POLDIP2 26073
Proximity Label-MS Homo sapiens
52 TMEM126B 55863
Proximity Label-MS Homo sapiens
53 CYC1 1537
Proximity Label-MS Homo sapiens
54 MICU1 10367
Proximity Label-MS Homo sapiens
55 NDUFAF3 25915
Proximity Label-MS Homo sapiens
56 CKMT1B 1159
Proximity Label-MS Homo sapiens
57 COX4I1 1327
Proximity Label-MS Homo sapiens
58 HNRNPD 3184
Two-hybrid Homo sapiens
59 MRPL40 64976
Proximity Label-MS Homo sapiens
60 COX5B 1329
Proximity Label-MS Homo sapiens
61 AK2 204
Proximity Label-MS Homo sapiens
62 SLC25A12 8604
Proximity Label-MS Homo sapiens
63 AIFM1 9131
Proximity Label-MS Homo sapiens
64 PNPT1 87178
Proximity Label-MS Homo sapiens
65 MRPS35 60488
Proximity Label-MS Homo sapiens
66 SDHA 6389
Proximity Label-MS Homo sapiens
67 LETM1 3954
Proximity Label-MS Homo sapiens
68 NFS1 9054
Proximity Label-MS Homo sapiens
69 ATP5F1 515
Proximity Label-MS Homo sapiens
70 PYCR2 29920
Proximity Label-MS Homo sapiens
71 ECHS1 1892
Proximity Label-MS Homo sapiens
72 FDFT1 2222
Proximity Label-MS Homo sapiens
73 TOMM70A 9868
Proximity Label-MS Homo sapiens
74 ACADSB 36
Proximity Label-MS Homo sapiens
75 YME1L1 10730
Proximity Label-MS Homo sapiens
76 APOOL 139322
Proximity Label-MS Homo sapiens
77 ACAD9 28976
Proximity Label-MS Homo sapiens
78 SIRT2 22933
Proximity Label-MS Homo sapiens
79 MRPS36 92259
Proximity Label-MS Homo sapiens
80 PDPR 55066
Proximity Label-MS Homo sapiens
81 CLPB 81570
Proximity Label-MS Homo sapiens
82 PARL  
Proximity Label-MS Homo sapiens
83 NDUFA12 55967
Proximity Label-MS Homo sapiens
84 NDUFV2 4729
Proximity Label-MS Homo sapiens
85 PPIF 10105
Proximity Label-MS Homo sapiens
86 IMMT 10989
Proximity Label-MS Homo sapiens
87 HSPE1 3336
Proximity Label-MS Homo sapiens
88 GLS 2744
Proximity Label-MS Homo sapiens
89 CCDC58 131076
Proximity Label-MS Homo sapiens
90 C17orf80 55028
Proximity Label-MS Homo sapiens
91 NME4 4833
Proximity Label-MS Homo sapiens
92 COX5A 9377
Proximity Label-MS Homo sapiens
93 NDUFS7 374291
Proximity Label-MS Homo sapiens
94 GRPEL1 80273
Proximity Label-MS Homo sapiens
95 SHMT2 6472
Proximity Label-MS Homo sapiens
96 ATAD3A 55210
Proximity Label-MS Homo sapiens
97 NDUFS8 4728
Proximity Label-MS Homo sapiens
98 GFM1 85476
Proximity Label-MS Homo sapiens
99 ACOT1 641371
Proximity Label-MS Homo sapiens
100 NDUFAF4 29078
Proximity Label-MS Homo sapiens
101 RAC1 5879
Proximity Label-MS Homo sapiens
102 MRPS22 56945
Proximity Label-MS Homo sapiens
103 ND4 4538
Proximity Label-MS Homo sapiens
104 TIMM13 26517
Proximity Label-MS Homo sapiens
105 TIMM44 10469
Proximity Label-MS Homo sapiens
106 ECSIT 51295
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IMMP2L is involved
No pathways found





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