Gene description for SLC4A11
Gene name solute carrier family 4, sodium borate transporter, member 11
Gene symbol SLC4A11
Other names/aliases BTR1
CDPD1
CHED2
NABC1
dJ794I6.2
Species Homo sapiens
 Database cross references - SLC4A11
ExoCarta ExoCarta_83959
Entrez Gene 83959
HGNC 16438
MIM 610206
UniProt Q8NBS3  
 SLC4A11 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SLC4A11
Molecular Function
    borate transmembrane transporter activity GO:0046715 IDA
    symporter activity GO:0015293 IEA
    sodium channel activity GO:0005272 IDA
    bicarbonate transmembrane transporter activity GO:0015106 IDA
    inorganic anion exchanger activity GO:0005452 IEA
    hydrogen ion channel activity GO:0015252 IDA
    protein dimerization activity GO:0046983 IDA
Biological Process
    regulation of intracellular pH GO:0051453 IBA
    borate transport GO:0046713 IDA
    bicarbonate transport GO:0015701 IDA
    cellular cation homeostasis GO:0030003 IDA
    sodium ion transport GO:0006814 IDA
    borate transmembrane transport GO:0035445 IDA
    sodium ion transmembrane transport GO:0035725 IDA
    fluid transport GO:0042044 ISS
    proton transport GO:0015992 IDA
Subcellular Localization
    basolateral plasma membrane GO:0016323 TAS
    integral component of plasma membrane GO:0005887 IBA
 Experiment description of studies that identified SLC4A11 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC4A11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC4A11 is involved
No pathways found





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