Gene description for Pon1
Gene name paraoxonase 1
Gene symbol Pon1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Pon1
ExoCarta ExoCarta_84024
Entrez Gene 84024
UniProt P55159  
 Pon1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Pon1
Molecular Function
    aryldialkylphosphatase activity GO:0004063 ISS
    phospholipid binding GO:0005543 ISO
    protein homodimerization activity GO:0042803 ISO
    calcium ion binding GO:0005509 ISS
    arylesterase activity GO:0004064 ISS
Biological Process
    response to nutrient levels GO:0031667 IEP
    positive regulation of cholesterol efflux GO:0010875 ISO
    response to toxic substance GO:0009636 ISO
    phosphatidylcholine metabolic process GO:0046470 ISO
    positive regulation of transporter activity GO:0032411 ISO
    organophosphate catabolic process GO:0046434 ISO
    carboxylic acid catabolic process GO:0046395 ISO
    dephosphorylation GO:0016311 ISS
    negative regulation of plasma lipoprotein particle oxidation GO:0034445 ISO
    response to fatty acid GO:0070542 IEP
    lipid metabolic process GO:0006629 IEP
    positive regulation of binding GO:0051099 ISO
    aromatic compound catabolic process GO:0019439 ISO
    response to fluoride GO:1902617 IDA
    cholesterol metabolic process GO:0008203 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    intracellular membrane-bounded organelle GO:0043231 IDA
    spherical high-density lipoprotein particle GO:0034366 ISO
    extracellular space GO:0005615 ISO
    blood microparticle GO:0072562 ISO
    high-density lipoprotein particle GO:0034364 ISO
 Experiment description of studies that identified Pon1 in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Pon1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pon1 is involved
No pathways found





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