Gene description for ZNF541
Gene name zinc finger protein 541
Gene symbol ZNF541
Other names/aliases -
Species Homo sapiens
 Database cross references - ZNF541
ExoCarta ExoCarta_84215
Vesiclepedia VP_84215
Entrez Gene 84215
HGNC 25294
UniProt Q9H0D2  
 ZNF541 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for ZNF541
Molecular Function
    transcription corepressor activity GO:0003714 IBA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    regulation of DNA-templated transcription GO:0006355 ISS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    male meiotic nuclear division GO:0007140 ISS
    spermatogenesis GO:0007283 IEA
    cell differentiation GO:0030154 IEA
    negative regulation of DNA-templated transcription GO:0045892 IBA
    negative regulation of DNA-templated transcription GO:0045892 ISS
    positive regulation of DNA-templated transcription GO:0045893 ISS
Subcellular Localization
    histone deacetylase complex GO:0000118 IBA
    histone deacetylase complex GO:0000118 ISS
    nucleus GO:0005634 ISS
    transcription regulator complex GO:0005667 IBA
 Experiment description of studies that identified ZNF541 in sEVs
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ZNF541
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AJUBA  
Two-hybrid Homo sapiens
2 RPL13A 23521
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF541 is involved
No pathways found





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