Gene description for Abcd2
Gene name ATP-binding cassette, subfamily D (ALD), member 2
Gene symbol Abcd2
Other names/aliases ALDR
Species Rattus norvegicus
 Database cross references - Abcd2
ExoCarta ExoCarta_84356
Vesiclepedia VP_84356
Entrez Gene 84356
UniProt Q9QY44  
 Abcd2 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Abcd2
Molecular Function
    long-chain fatty acid transmembrane transporter activity GO:0005324 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IBA
    ATP hydrolysis activity GO:0016887 ISO
    ATPase-coupled transmembrane transporter activity GO:0042626 IBA
    ATPase-coupled transmembrane transporter activity GO:0042626 ISO
    ATPase-coupled transmembrane transporter activity GO:0042626 ISS
    protein homodimerization activity GO:0042803 IDA
    protein homodimerization activity GO:0042803 ISO
    protein heterodimerization activity GO:0046982 IDA
    fatty acyl-CoA hydrolase activity GO:0047617 ISO
    fatty acyl-CoA hydrolase activity GO:0047617 ISS
    ABC-type transporter activity GO:0140359 IEA
Biological Process
    very long-chain fatty acid metabolic process GO:0000038 IMP
    very long-chain fatty acid metabolic process GO:0000038 ISO
    very long-chain fatty acid metabolic process GO:0000038 ISS
    fatty acid beta-oxidation GO:0006635 IBA
    fatty acid beta-oxidation GO:0006635 ISO
    peroxisome organization GO:0007031 IBA
    response to bacterium GO:0009617 ISO
    long-chain fatty acid import into peroxisome GO:0015910 IBA
    positive regulation of fatty acid beta-oxidation GO:0032000 ISO
    positive regulation of fatty acid beta-oxidation GO:0032000 ISS
    very long-chain fatty acid catabolic process GO:0042760 IBA
    very long-chain fatty acid catabolic process GO:0042760 IMP
    very long-chain fatty acid catabolic process GO:0042760 ISO
    very long-chain fatty acid catabolic process GO:0042760 ISS
    myelin maintenance GO:0043217 ISO
    myelin maintenance GO:0043217 ISS
    negative regulation of cytokine production involved in inflammatory response GO:1900016 ISO
    negative regulation of cytokine production involved in inflammatory response GO:1900016 ISS
    negative regulation of reactive oxygen species biosynthetic process GO:1903427 ISO
    negative regulation of reactive oxygen species biosynthetic process GO:1903427 ISS
    neuron projection maintenance GO:1990535 ISO
    neuron projection maintenance GO:1990535 ISS
    positive regulation of unsaturated fatty acid biosynthetic process GO:2001280 ISO
    positive regulation of unsaturated fatty acid biosynthetic process GO:2001280 ISS
Subcellular Localization
    peroxisome GO:0005777 IDA
    peroxisome GO:0005777 ISO
    peroxisomal membrane GO:0005778 IBA
    peroxisomal membrane GO:0005778 IDA
 Experiment description of studies that identified Abcd2 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Abcd2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Snca  
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here