Gene description for Rab6a
Gene name RAB6A, member RAS oncogene family
Gene symbol Rab6a
Other names/aliases RCO4-3
Rab6
Rab6b
Species Rattus norvegicus
 Database cross references - Rab6a
ExoCarta ExoCarta_84379
Entrez Gene 84379
UniProt Q9WVB1  
 Rab6a identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Rab6a
Molecular Function
    ATPase activator activity GO:0001671 IMP
    myosin V binding GO:0031489 ISO
    ATPase binding GO:0051117 IPI
    GTPase activity GO:0003924 TAS
    GTP binding GO:0005525 ISS
    protein domain specific binding GO:0019904 ISO
Biological Process
    early endosome to Golgi transport GO:0034498 ISO
    peptidyl-cysteine methylation GO:0018125 ISO
    retrograde vesicle-mediated transport, Golgi to ER GO:0006890 IBA
    intracellular protein transport GO:0006886 IBA
    antigen processing and presentation GO:0019882 ISO
    protein targeting to Golgi GO:0000042 ISS
    retrograde transport, endosome to Golgi GO:0042147 IBA
    Rab protein signal transduction GO:0032482 IC
    metabolic process GO:0008152 TAS
    protein localization to Golgi apparatus GO:0034067 ISO
    intra-Golgi vesicle-mediated transport GO:0006891 IBA
    Golgi vesicle transport GO:0048193 TAS
    positive regulation of ATPase activity GO:0032781 IDA
Subcellular Localization
    cytosol GO:0005829 ISO
    cytoplasmic vesicle GO:0031410 ISO
    Golgi apparatus GO:0005794 ISS
    trans-Golgi network GO:0005802 ISO
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 ISO
    Golgi membrane GO:0000139 IEA
 Experiment description of studies that identified Rab6a in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Rab6a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rab6a is involved
PathwayEvidenceSource
Pre-NOTCH Processing in Golgi IEA Reactome





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