Gene description for Fen1
Gene name	flap structure-specific endonuclease 1
Gene symbol	Fen1
Other names/aliases	FEN-1
Species	Rattus norvegicus
Database cross references - Fen1
ExoCarta	ExoCarta_84490
Vesiclepedia	VP_84490
Entrez Gene	84490
UniProt	Q5XIP6
Fen1 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Fen1

Molecular Function     magnesium ion binding GO:0000287 IBA     magnesium ion binding GO:0000287 ISO     DNA binding GO:0003677 ISO     RNA-DNA hybrid ribonuclease activity GO:0004523 IBA     RNA-DNA hybrid ribonuclease activity GO:0004523 ISO     exonuclease activity GO:0004527 ISO     exonuclease activity GO:0004527 NAS     5'-3' exonuclease activity GO:0008409 IBA     5'-3' exonuclease activity GO:0008409 ISO     5'-flap endonuclease activity GO:0017108 IBA     5'-flap endonuclease activity GO:0017108 ISO     manganese ion binding GO:0030145 IBA     manganese ion binding GO:0030145 ISO     flap endonuclease activity GO:0048256 ISO Biological Process     DNA replication GO:0006260 ISO     DNA repair GO:0006281 ISO     base-excision repair GO:0006284 IEA     memory GO:0007613 IMP     DNA replication, removal of RNA primer GO:0043137 ISO     positive regulation of sister chromatid cohesion GO:0045876 ISO Subcellular Localization     chromosome, telomeric region GO:0000781 ISO     nucleus GO:0005634 IBA     nucleus GO:0005634 ISO     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     nucleolus GO:0005730 IEA     nucleolus GO:0005730 ISO     mitochondrion GO:0005739 ISO     protein-containing complex GO:0032991 ISO