Gene description for Hamp
Gene name hepcidin antimicrobial peptide
Gene symbol Hamp
Other names/aliases Hamp1
Hepc
Hepc1
Species Mus musculus
 Database cross references - Hamp
ExoCarta ExoCarta_84506
Vesiclepedia VP_84506
Entrez Gene 84506
UniProt Q9EQ21  
 Hamp identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Hamp
Molecular Function
    signaling receptor binding GO:0005102 ISO
    hormone activity GO:0005179 IEA
    hormone activity GO:0005179 ISO
    copper ion binding GO:0005507 IDA
    iron ion transmembrane transporter inhibitor activity GO:0097690 ISO
    transporter regulator activity GO:0141108 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    positive regulation of receptor internalization GO:0002092 ISO
    myeloid cell homeostasis GO:0002262 IMP
    transcription by RNA polymerase II GO:0006366 IGI
    intracellular iron ion homeostasis GO:0006879 IBA
    intracellular iron ion homeostasis GO:0006879 IDA
    intracellular iron ion homeostasis GO:0006879 ISO
    inflammatory response GO:0006954 IGI
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IDA
    response to iron ion GO:0010039 IEA
    response to iron ion GO:0010039 ISO
    protein catabolic process GO:0030163 IDA
    killing of cells of another organism GO:0031640 ISO
    negative regulation of ion transmembrane transporter activity GO:0032413 ISO
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IEA
    iron ion transmembrane transport GO:0034755 IGI
    negative regulation of iron ion transmembrane transport GO:0034760 IBA
    negative regulation of iron ion transmembrane transport GO:0034760 IGI
    macrophage activation GO:0042116 IMP
    defense response to bacterium GO:0042742 IBA
    defense response to bacterium GO:0042742 IDA
    defense response to bacterium GO:0042742 IMP
    positive regulation of macrophage activation GO:0043032 IMP
    positive regulation of protein catabolic process GO:0045732 IDA
    negative regulation of bone resorption GO:0045779 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IGI
    negative regulation of inflammatory response GO:0050728 IGI
    defense response to Gram-negative bacterium GO:0050829 ISO
    defense response to Gram-positive bacterium GO:0050830 ISO
    defense response to fungus GO:0050832 IDA
    defense response to fungus GO:0050832 ISO
    establishment of localization in cell GO:0051649 IGI
    multicellular organismal-level iron ion homeostasis GO:0060586 IDA
    multicellular organismal-level iron ion homeostasis GO:0060586 IMP
    multicellular organismal-level iron ion homeostasis GO:0060586 ISO
    positive regulation of cell growth involved in cardiac muscle cell development GO:0061051 ISO
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 ISO
    positive regulation of protein polyubiquitination GO:1902916 ISO
    negative regulation of iron export across plasma membrane GO:1904039 IEA
    negative regulation of iron export across plasma membrane GO:1904039 ISO
    negative regulation of intestinal absorption GO:1904479 IEA
    negative regulation of intestinal absorption GO:1904479 ISO
    positive regulation of receptor catabolic process GO:2000646 ISO
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
    nucleus GO:0005634 IDA
    intercalated disc GO:0014704 ISO
    apical cortex GO:0045179 ISO
 Experiment description of studies that identified Hamp in exosomes
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Hamp
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hamp is involved
No pathways found





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