Gene description for Hamp
Gene name hepcidin antimicrobial peptide
Gene symbol Hamp
Other names/aliases Hamp1
Hepc
Hepc1
Species Mus musculus
 Database cross references - Hamp
ExoCarta ExoCarta_84506
Entrez Gene 84506
UniProt Q9EQ21  
 Hamp identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Hamp
Molecular Function
    hormone activity GO:0005179 IEA
    copper ion binding GO:0005507 IDA
Biological Process
    iron ion homeostasis GO:0055072 IMP
    positive regulation of macrophage activation GO:0043032 IMP
    myeloid cell homeostasis GO:0002262 IMP
    negative regulation of inflammatory response GO:0050728 IGI
    cellular iron ion homeostasis GO:0006879 IGI
    negative regulation of iron ion transmembrane transport GO:0034760 IGI
    defense response to fungus GO:0050832 IDA
    negative regulation of bone resorption GO:0045779 IMP
    JAK-STAT cascade GO:0007259 IDA
    positive regulation of cellular protein catabolic process GO:1903364 IDA
    defense response to bacterium GO:0042742 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IGI
Subcellular Localization
    cell GO:0005623 IGI
    extracellular space GO:0005615 IDA
    extracellular region GO:0005576 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Hamp in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Hamp
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hamp is involved
No pathways found





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