Gene description for SYTL1
Gene name synaptotagmin-like 1
Gene symbol SYTL1
Other names/aliases JFC1
SLP1
Species Homo sapiens
 Database cross references - SYTL1
ExoCarta ExoCarta_84958
Entrez Gene 84958
HGNC 15584
MIM 608042
UniProt Q8IYJ3  
 SYTL1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for SYTL1
Molecular Function
    calcium ion binding GO:0005509 IBA
    Rab GTPase binding GO:0017137 IEA
    protein binding GO:0005515 IPI
    syntaxin binding GO:0019905 IBA
    clathrin binding GO:0030276 IBA
    neurexin family protein binding GO:0042043 ISS
    calcium-dependent phospholipid binding GO:0005544 IBA
Biological Process
    exocytosis GO:0006887 IDA
    calcium ion-dependent exocytosis of neurotransmitter GO:0048791 IBA
    regulation of calcium ion-dependent exocytosis GO:0017158 IBA
    intracellular protein transport GO:0006886 IEA
    synaptic vesicle exocytosis GO:0016079 IBA
Subcellular Localization
    melanosome GO:0042470 ISS
    plasma membrane GO:0005886 IDA
    extracellular exosome GO:0070062 IDA
    extrinsic component of plasma membrane GO:0019897 ISS
    exocytic vesicle GO:0070382 IBA
 Experiment description of studies that identified SYTL1 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 193
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
PHB
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 194
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 195
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SYTL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAB27A 5873
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
2 NCF1  
Reconstituted Complex Homo sapiens
3 NCF2 4688
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SYTL1 is involved
No pathways found





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