Gene description for Plg
Gene name plasminogen
Gene symbol Plg
Other names/aliases Ab1-346
Species Rattus norvegicus
 Database cross references - Plg
ExoCarta ExoCarta_85253
Vesiclepedia VP_85253
Entrez Gene 85253
UniProt Q01177  
 Plg identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Plg
Molecular Function
    protease binding GO:0002020 ISO
    endopeptidase activity GO:0004175 IBA
    endopeptidase activity GO:0004175 IDA
    endopeptidase activity GO:0004175 ISO
    serine-type endopeptidase activity GO:0004252 IEA
    serine-type endopeptidase activity GO:0004252 ISO
    signaling receptor binding GO:0005102 IBA
    signaling receptor binding GO:0005102 ISO
    enzyme binding GO:0019899 IPI
    enzyme binding GO:0019899 ISO
    kinase binding GO:0019900 IEA
    kinase binding GO:0019900 ISO
    protein domain specific binding GO:0019904 ISO
    apolipoprotein binding GO:0034185 ISO
    protein-folding chaperone binding GO:0051087 ISO
    protein antigen binding GO:1990405 ISO
Biological Process
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 IEA
    proteolysis GO:0006508 ISO
    blood coagulation GO:0007596 IEA
    blood coagulation GO:0007596 ISO
    negative regulation of cell-substrate adhesion GO:0010812 ISO
    protein processing GO:0016485 IEA
    protein processing GO:0016485 ISO
    extracellular matrix disassembly GO:0022617 ISO
    tissue regeneration GO:0042246 IEA
    tissue regeneration GO:0042246 ISO
    fibrinolysis GO:0042730 IEA
    fibrinolysis GO:0042730 ISO
    positive regulation of blood vessel endothelial cell migration GO:0043536 ISO
    myoblast differentiation GO:0045445 IEA
    myoblast differentiation GO:0045445 ISO
    muscle cell cellular homeostasis GO:0046716 IEA
    muscle cell cellular homeostasis GO:0046716 ISO
    tissue remodeling GO:0048771 IEA
    proteolysis involved in protein catabolic process GO:0051603 IDA
    negative regulation of fibrinolysis GO:0051918 ISO
    positive regulation of fibrinolysis GO:0051919 ISO
    trophoblast giant cell differentiation GO:0060707 IEA
    trophoblast giant cell differentiation GO:0060707 ISO
    labyrinthine layer blood vessel development GO:0060716 IEA
    labyrinthine layer blood vessel development GO:0060716 ISO
    mononuclear cell migration GO:0071674 IEA
    mononuclear cell migration GO:0071674 ISO
    trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 IEA
    trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
    external side of plasma membrane GO:0009897 ISO
    cell surface GO:0009986 IEA
    cell surface GO:0009986 ISO
    membrane GO:0016020 IEA
    Schaffer collateral - CA1 synapse GO:0098685 IEA
    Schaffer collateral - CA1 synapse GO:0098685 ISO
    glutamatergic synapse GO:0098978 IEA
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Plg in sEVs
1
Experiment ID 95
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Plg
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mib1  
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml



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