Gene description for Plg
Gene name plasminogen
Gene symbol Plg
Other names/aliases Ab1-346
Species Rattus norvegicus
 Database cross references - Plg
ExoCarta ExoCarta_85253
Entrez Gene 85253
UniProt Q01177  
 Plg identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Plg
Molecular Function
    receptor binding GO:0005102 ISO
    apolipoprotein binding GO:0034185 ISO
    protein domain specific binding GO:0019904 ISO
    serine-type endopeptidase activity GO:0004252 ISO
    endopeptidase activity GO:0004175 IDA
    fibronectin binding GO:0001968 IEA
Biological Process
    labyrinthine layer blood vessel development GO:0060716 ISO
    proteolysis involved in cellular protein catabolic process GO:0051603 IDA
    negative regulation of fibrinolysis GO:0051918 ISO
    positive regulation of fibrinolysis GO:0051919 ISO
    extracellular matrix disassembly GO:0022617 ISO
    blood coagulation GO:0007596 ISO
    negative regulation of cell-substrate adhesion GO:0010812 ISO
    fibrinolysis GO:0042730 IEA
    trophoblast giant cell differentiation GO:0060707 ISO
    tissue regeneration GO:0042246 ISO
    muscle cell cellular homeostasis GO:0046716 ISO
    tissue remodeling GO:0048771 IEA
    myoblast differentiation GO:0045445 ISO
    mononuclear cell migration GO:0071674 ISO
Subcellular Localization
    extrinsic component of external side of plasma membrane GO:0031232 ISO
    intracellular membrane-bounded organelle GO:0043231 IDA
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 ISO
    plasma lipoprotein particle GO:0034358 IEA
    blood microparticle GO:0072562 ISO
    extrinsic component of plasma membrane GO:0019897 ISO
    cell surface GO:0009986 ISO
    cell GO:0005623 ISO
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified Plg in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Plg
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Plg is involved
PathwayEvidenceSource
LDL-mediated lipid transport IEA Reactome





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