Gene description for Lrp3
Gene name low density lipoprotein receptor-related protein 3
Gene symbol Lrp3
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Lrp3
ExoCarta ExoCarta_89787
Vesiclepedia VP_89787
Entrez Gene 89787
UniProt O88204  
 Lrp3 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Lrp3
Biological Process
    endocytosis GO:0006897 IEA
    biological_process GO:0008150 ND
    positive regulation of gene expression GO:0010628 IEA
    positive regulation of gene expression GO:0010628 ISO
    negative regulation of gene expression GO:0010629 IEA
    negative regulation of gene expression GO:0010629 ISO
    negative regulation of fat cell differentiation GO:0045599 IEA
    negative regulation of fat cell differentiation GO:0045599 ISO
    positive regulation of osteoblast differentiation GO:0045669 IEA
    positive regulation of osteoblast differentiation GO:0045669 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    clathrin-coated pit GO:0005905 IEA
 Experiment description of studies that identified Lrp3 in exosomes
1
Experiment ID 192
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Lrp3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lrp3 is involved
No pathways found





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