Gene description for Ftcd
Gene name formimidoyltransferase cyclodeaminase
Gene symbol Ftcd
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ftcd
ExoCarta ExoCarta_89833
Vesiclepedia VP_89833
Entrez Gene 89833
UniProt O88618  
 Ftcd identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Ftcd
Molecular Function
    folic acid binding GO:0005542 IEA
    microtubule binding GO:0008017 IDA
    microtubule binding GO:0008017 ISO
    intermediate filament binding GO:0019215 TAS
    glutamate formimidoyltransferase activity GO:0030409 IDA
    glutamate formimidoyltransferase activity GO:0030409 ISO
    glutamate formimidoyltransferase activity GO:0030409 TAS
    formimidoyltetrahydrofolate cyclodeaminase activity GO:0030412 IDA
    formimidoyltetrahydrofolate cyclodeaminase activity GO:0030412 ISO
    formimidoyltetrahydrofolate cyclodeaminase activity GO:0030412 TAS
Biological Process
    cytoskeleton organization GO:0007010 IMP
    L-histidine catabolic process to glutamate and formamide GO:0019556 IEA
    L-histidine catabolic process to glutamate and formate GO:0019557 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    Golgi membrane GO:0000139 ISO
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IDA
    Golgi apparatus GO:0005794 ISO
    centriole GO:0005814 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    smooth endoplasmic reticulum membrane GO:0030868 ISO
 Experiment description of studies that identified Ftcd in sEVs
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Ftcd
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ftcd is involved
PathwayEvidenceSource
Histidine catabolism IEA Reactome
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome





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