Gene description for Ftcd
Gene name formimidoyltransferase cyclodeaminase
Gene symbol Ftcd
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ftcd
ExoCarta ExoCarta_89833
Entrez Gene 89833
UniProt O88618  
 Ftcd identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Ftcd
Molecular Function
    glutamate formimidoyltransferase activity GO:0030409 TAS
    folic acid binding GO:0005542 IEA
    formimidoyltetrahydrofolate cyclodeaminase activity GO:0030412 TAS
    intermediate filament binding GO:0019215 TAS
Biological Process
    tetrahydrofolate interconversion GO:0035999 IEA
    cytoskeleton organization GO:0007010 IMP
    histidine catabolic process to glutamate and formate GO:0019557 IEA
    histidine catabolic process to glutamate and formamide GO:0019556 IEA
Subcellular Localization
    Golgi apparatus GO:0005794 ISO
    centriole GO:0005814 IEA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Ftcd in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Ftcd
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ftcd is involved
PathwayEvidenceSource
Histidine catabolism IEA Reactome





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