Gene description for Cxadr
Gene name coxsackie virus and adenovirus receptor
Gene symbol Cxadr
Other names/aliases Car1
Species Rattus norvegicus
 Database cross references - Cxadr
ExoCarta ExoCarta_89843
Entrez Gene 89843
UniProt Q9R066  
 Cxadr identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Cxadr
Molecular Function
    identical protein binding GO:0042802 ISO
    beta-catenin binding GO:0008013 ISS
    cell adhesion molecule binding GO:0050839 ISS
    connexin binding GO:0071253 ISS
    integrin binding GO:0005178 ISO
    PDZ domain binding GO:0030165 ISS
    receptor binding GO:0005102 ISO
    virus receptor activity GO:0001618 TAS
Biological Process
    germ cell migration GO:0008354 ISS
    heart development GO:0007507 ISS
    epithelial structure maintenance GO:0010669 ISS
    regulation of AV node cell action potential GO:0098904 ISO
    mitochondrion organization GO:0007005 ISS
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISS
    homotypic cell-cell adhesion GO:0034109 ISS
    gamma-delta T cell activation GO:0046629 ISS
    actin cytoskeleton reorganization GO:0031532 ISS
    single organismal cell-cell adhesion GO:0016337 ISO
    cardiac muscle fiber development GO:0048739 ISS
    neutrophil chemotaxis GO:0030593 ISS
    viral entry into host cell GO:0046718 TAS
    transepithelial transport GO:0070633 ISO
    defense response to virus GO:0051607 ISO
    negative regulation of cardiac muscle cell proliferation GO:0060044 ISO
    AV node cell to bundle of His cell communication GO:0086067 ISS
    AV node cell-bundle of His cell adhesion involved in cell communication GO:0086072 ISO
    cell-cell junction organization GO:0045216 ISS
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    acrosomal vesicle GO:0001669 ISS
    cytoplasm GO:0005737 ISS
    cell body GO:0044297 ISS
    nucleus GO:0005634 ISS
    neuron projection GO:0043005 ISO
    plasma membrane GO:0005886 ISS
    intercalated disc GO:0014704 ISO
    growth cone GO:0030426 ISS
    integral component of membrane GO:0016021 IEA
    membrane raft GO:0045121 ISS
    filopodium GO:0030175 ISS
    extracellular space GO:0005615 ISO
    apicolateral plasma membrane GO:0016327 ISS
    neuromuscular junction GO:0031594 ISO
    basolateral plasma membrane GO:0016323 ISO
    protein complex GO:0043234 ISO
    cell-cell junction GO:0005911 ISO
    adherens junction GO:0005912 ISS
    cell junction GO:0030054 ISO
    bicellular tight junction GO:0005923 ISO
 Experiment description of studies that identified Cxadr in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 94
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Cxadr
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cxadr is involved
No pathways found





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