Gene description for CD1C
Gene name CD1c molecule
Gene symbol CD1C
Other names/aliases BDCA1
CD1
CD1A
R7
Species Homo sapiens
 Database cross references - CD1C
ExoCarta ExoCarta_911
Vesiclepedia VP_911
Entrez Gene 911
HGNC 1636
MIM 188340
UniProt P29017  
 CD1C identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CD1C
Molecular Function
    protein binding GO:0005515 IPI
    endogenous lipid antigen binding GO:0030883 IBA
    endogenous lipid antigen binding GO:0030883 IDA
    exogenous lipid antigen binding GO:0030884 IBA
    exogenous lipid antigen binding GO:0030884 IDA
    glycolipid binding GO:0051861 IDA
    lipopeptide binding GO:0071723 IBA
    lipopeptide binding GO:0071723 IDA
Biological Process
    positive regulation of T cell mediated cytotoxicity GO:0001916 IBA
    adaptive immune response GO:0002250 IEA
    T cell activation involved in immune response GO:0002286 IDA
    immune response GO:0006955 IBA
    antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 IBA
    antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
    lysosome GO:0005764 IEA
    endoplasmic reticulum GO:0005783 IDA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    endosome membrane GO:0010008 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified CD1C in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD1C
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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