|
Gene description for CACNA2D4 |
| Gene name |
calcium channel, voltage-dependent, alpha 2/delta subunit 4 |
| Gene symbol |
CACNA2D4 |
| Other names/aliases |
RCD4 |
| Species |
Homo sapiens |
Database cross references - CACNA2D4 |
| ExoCarta |
ExoCarta_93589 |
| Vesiclepedia |
VP_93589 |
| Entrez Gene |
93589 |
| HGNC |
20202 |
| MIM |
608171 |
| UniProt |
Q7Z3S7
|
CACNA2D4 identified in sEVs derived from the following tissue/cell type |
|
Hepatocytes
|
26054723
|
|
Mesenchymal stem cells
|
Unpublished / Not applicable
|
Gene ontology annotations for CACNA2D4 |
|
|
Experiment description of studies that identified CACNA2D4 in sEVs |
| 1 |
| Experiment ID |
237 |
| MISEV standards |
|
✔
EM
|
Biophysical techniques |
|
✔
TSG101|Alix|HSC70|GAPDH
|
Enriched markers |
|
✔
HSP90B1
|
Negative markers |
|
✔
qNano
|
Particle analysis
|
|
| Identified molecule |
mRNA
|
| Identification method |
RNA Sequencing
|
| PubMed ID |
26054723
|
| Organism |
Homo sapiens |
| Experiment description |
Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs |
| Authors |
"He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N" |
| Journal name |
Carcinogenesis
|
| Publication year |
2015 |
| Sample |
Hepatocytes |
| Sample name |
MIHA |
| Isolation/purification methods |
Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient |
| Flotation density |
1.13-1.19 g/mL
|
| Molecules identified in the study |
Protein RNA |
| Methods used in the study |
Western blotting Mass spectrometry RNA Sequencing |
|
|
| 2 |
| Experiment ID |
126 |
| MISEV standards |
|
✘
|
Biophysical techniques |
|
✔
GAPDH
|
Enriched markers |
|
✘
|
Negative markers |
|
✘
|
Particle analysis
|
|
| Identified molecule |
protein
|
| Identification method |
Mass spectrometry [LTQ-FT Ultra]
|
| PubMed ID |
Unpublished / Not applicable
|
| Organism |
Homo sapiens |
| Experiment description |
Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy? |
| Authors |
"Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim" |
| Journal name |
Mesenchymal Stem Cell Therapy
|
| Publication year |
2011 |
| Sample |
Mesenchymal stem cells |
| Sample name |
huES9.E1 |
| Isolation/purification methods |
HPLC |
| Flotation density |
-
|
| Molecules identified in the study |
Protein |
| Methods used in the study |
Western blotting Antobody array Mass spectrometry |
|
|
Protein-protein interactions for CACNA2D4 |
| |
Protein Interactor |
ExoCarta ID |
Identification method |
PubMed |
Species |
|
No interactions are found.
|
|
Pathways in which CACNA2D4 is involved |
|
No pathways found
|
|
|