Gene description for KL
Gene name klotho
Gene symbol KL
Other names/aliases -
Species Homo sapiens
 Database cross references - KL
ExoCarta ExoCarta_9365
Entrez Gene 9365
HGNC 6344
MIM 604824
UniProt Q9UEF7  
 KL identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for KL
Molecular Function
    beta-glucuronidase activity GO:0004566 IEA
    hormone activity GO:0005179 IEA
    vitamin D binding GO:0005499 IEA
    fibroblast growth factor binding GO:0017134 IPI
    signal transducer activity GO:0004871 IEA
    fibroblast growth factor receptor binding GO:0005104 IEA
    beta-glucosidase activity GO:0008422 TAS
Biological Process
    energy reserve metabolic process GO:0006112 IEA
    positive regulation of bone mineralization GO:0030501 IMP
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    acute inflammatory response GO:0002526 IEA
    insulin receptor signaling pathway GO:0008286 TAS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    carbohydrate metabolic process GO:0005975 IEA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 IEA
    aging GO:0007568 IMP
    calcium ion homeostasis GO:0055074 IEA
    innate immune response GO:0045087 TAS
Subcellular Localization
    extracellular space GO:0005615 TAS
    integral component of plasma membrane GO:0005887 TAS
    extracellular region GO:0005576 TAS
    integral component of membrane GO:0016021 TAS
    intracellular GO:0005622 TAS
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified KL in exosomes
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for KL
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which KL is involved
No pathways found

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