Gene description for Klf7
Gene name Kruppel-like factor 7 (ubiquitous)
Gene symbol Klf7
Other names/aliases 9830124P08Rik
Species Mus musculus
 Database cross references - Klf7
ExoCarta ExoCarta_93691
Vesiclepedia VP_93691
Entrez Gene 93691
UniProt Q99JB0  
 Klf7 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Klf7
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IEA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISO
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IEA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 ISO
    DNA binding GO:0003677 IDA
    DNA binding GO:0003677 ISS
    DNA-binding transcription factor activity GO:0003700 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    axonogenesis GO:0007409 IMP
    axon guidance GO:0007411 IMP
    glucose homeostasis GO:0042593 ISO
    glucose homeostasis GO:0042593 ISS
    regulation of epidermal cell differentiation GO:0045604 IEA
    regulation of epidermal cell differentiation GO:0045604 ISO
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    dendrite morphogenesis GO:0048813 IMP
    negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179 ISO
    negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179 ISS
    negative regulation of adipose tissue development GO:1904178 ISO
    negative regulation of adipose tissue development GO:1904178 ISS
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Klf7 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Klf7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Klf7 is involved
No pathways found





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