Gene description for Gpnmb
Gene name	glycoprotein (transmembrane) nmb
Gene symbol	Gpnmb
Other names/aliases	DC-HIL Dchil ipd
Species	Mus musculus
Database cross references - Gpnmb
ExoCarta	ExoCarta_93695
Vesiclepedia	VP_93695
Entrez Gene	93695
UniProt	Q99P91
Gpnmb identified in sEVs derived from the following tissue/cell type
Brain cancer cells	19109410

Gene ontology annotations for Gpnmb

Molecular Function     integrin binding GO:0005178 IBA     integrin binding GO:0005178 IDA     heparin binding GO:0008201 IDA     heparin binding GO:0008201 ISO     syndecan binding GO:0045545 IEA     syndecan binding GO:0045545 ISO     receptor ligand activity GO:0048018 IEA     receptor ligand activity GO:0048018 ISO Biological Process     osteoblast differentiation GO:0001649 IEA     negative regulation of cytokine production GO:0001818 ISO     positive regulation of protein phosphorylation GO:0001934 IDA     positive regulation of protein phosphorylation GO:0001934 IMP     positive regulation of protein phosphorylation GO:0001934 ISO     cell adhesion GO:0007155 IBA     cell adhesion GO:0007155 IDA     signal transduction GO:0007165 IEA     signal transduction GO:0007165 ISO     cell-cell signaling GO:0007267 IEA     cell-cell signaling GO:0007267 ISO     bone mineralization GO:0030282 IEA     positive regulation of cell migration GO:0030335 IEA     positive regulation of cell migration GO:0030335 ISO     positive regulation of protein autophosphorylation GO:0031954 ISO     negative regulation of tumor necrosis factor production GO:0032720 IMP     regulation of tissue remodeling GO:0034103 IMP     regulation of tissue remodeling GO:0034103 ISO     negative regulation of T cell proliferation GO:0042130 IEA     negative regulation of T cell proliferation GO:0042130 ISO     negative regulation of T cell activation GO:0050868 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 IC     positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA     negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IEA     negative regulation of G1/S transition of mitotic cell cycle GO:2000134 ISO Subcellular Localization     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     membrane GO:0016020 ISO     cytoplasmic vesicle GO:0031410 IDA     early endosome membrane GO:0031901 IEA     melanosome membrane GO:0033162 IEA