Gene description for Gpnmb
Gene name glycoprotein (transmembrane) nmb
Gene symbol Gpnmb
Other names/aliases DC-HIL
Dchil
ipd
Species Mus musculus
 Database cross references - Gpnmb
ExoCarta ExoCarta_93695
Entrez Gene 93695
UniProt Q99P91  
 Gpnmb identified in exosomes derived from the following tissue/cell type
Brain cancer cells 19109410    
 Gene ontology annotations for Gpnmb
Molecular Function
    heparin binding GO:0008201 IDA
    integrin binding GO:0005178 IDA
Biological Process
    cell adhesion GO:0007155 IDA
Subcellular Localization
    integral component of plasma membrane GO:0005887 IDA
    plasma membrane GO:0005886 IEA
    integral component of membrane GO:0016021 IEA
    cytoplasmic membrane-bounded vesicle GO:0016023 IDA
    membrane GO:0016020 IEA
    cytoplasmic vesicle GO:0031410 IEA
 Experiment description of studies that identified Gpnmb in exosomes
1
Experiment ID 26
ISEV standards
EM
EV Biophysical techniques
Alix|GAPDH|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 19109410    
Organism Mus musculus
Experiment description Proteomic and immunologic analyses of brain tumor exosomes.
Authors Graner MW, Alzate O, Dechkovskaia AM, Keene JD, Sampson JH, Mitchell DA, Bigner DD
Journal name FASEB
Publication year 2008
Sample Brain cancer cells
Sample name SMA560vIII
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
 Protein-protein interactions for Gpnmb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gpnmb is involved
No pathways found





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