Gene description for Mcoln1
Gene name	mucolipin 1
Gene symbol	Mcoln1
Other names/aliases	2210015I05Rik TRPML1 mucolipidin
Species	Mus musculus
Database cross references - Mcoln1
ExoCarta	ExoCarta_94178
Vesiclepedia	VP_94178
Entrez Gene	94178
UniProt	Q99J21
Mcoln1 identified in sEVs derived from the following tissue/cell type
Melanoma cells	34957415
Melanoma cells	34957415
Melanoma cells	34957415

Gene ontology annotations for Mcoln1

Molecular Function     monoatomic anion channel activity GO:0005253 IDA     monoatomic cation channel activity GO:0005261 ISO     calcium channel activity GO:0005262 IDA     calcium channel activity GO:0005262 ISO     potassium channel activity GO:0005267 IDA     sodium channel activity GO:0005272 IDA     iron ion transmembrane transporter activity GO:0005381 IMP     iron ion transmembrane transporter activity GO:0005381 ISO     protein binding GO:0005515 IPI     lipid binding GO:0008289 IEA     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     NAADP-sensitive calcium-release channel activity GO:0072345 IBA     NAADP-sensitive calcium-release channel activity GO:0072345 IEA     NAADP-sensitive calcium-release channel activity GO:0072345 ISO     intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity GO:0097682 IDA     ligand-gated calcium channel activity GO:0099604 ISO Biological Process     adaptive immune response GO:0002250 IEA     endosomal transport GO:0016197 ISO     calcium-mediated signaling GO:0019722 IEA     iron ion transmembrane transport GO:0034755 IMP     iron ion transmembrane transport GO:0034755 ISO     sodium ion transmembrane transport GO:0035725 IEA     release of sequestered calcium ion into cytosol GO:0051209 IEA     release of sequestered calcium ion into cytosol GO:0051209 ISO     protein homotetramerization GO:0051289 IDA     protein homotetramerization GO:0051289 ISO     calcium ion transmembrane transport GO:0070588 ISO     cellular response to calcium ion GO:0071277 IMP     cellular response to pH GO:0071467 IMP     potassium ion transmembrane transport GO:0071805 IEA     phagosome maturation GO:0090382 IDA     phagosome maturation GO:0090382 ISO     autophagosome maturation GO:0097352 IMP     monoatomic cation transmembrane transport GO:0098655 IDA     monoatomic anion transmembrane transport GO:0098656 IEA     calcium ion export GO:1901660 ISO     calcium ion export GO:1901660 ISS     positive regulation of lysosome organization GO:1905673 ISO     positive regulation of lysosome organization GO:1905673 ISS Subcellular Localization     phagocytic cup GO:0001891 IEA     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     lysosome GO:0005764 ISO     lysosome GO:0005764 ISS     lysosomal membrane GO:0005765 IBA     lysosomal membrane GO:0005765 ISO     lysosomal membrane GO:0005765 ISO     lysosomal membrane GO:0005765 ISS     late endosome GO:0005770 ISO     late endosome GO:0005770 ISS     Golgi apparatus GO:0005794 IEA     Golgi apparatus GO:0005794 ISO     plasma membrane GO:0005886 IBA     membrane GO:0016020 IDA     membrane GO:0016020 ISO     phagocytic vesicle membrane GO:0030670 IEA     late endosome membrane GO:0031902 IEA     cell projection GO:0042995 IEA     intracellular membrane-bounded organelle GO:0043231 ISO     receptor complex GO:0043235 ISO     intracellular vesicle GO:0097708 EXP