Gene description for Rab14
Gene name RAB14, member RAS oncogene family
Gene symbol Rab14
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Rab14
ExoCarta ExoCarta_94197
Vesiclepedia VP_94197
Entrez Gene 94197
UniProt P61107  
 Rab14 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Rab14
Molecular Function
    protein binding GO:0005515 IPI
    myosin V binding GO:0031489 ISO
    GTPase activity GO:0003924 NAS
    GDP binding GO:0019003 ISS
    glycoprotein binding GO:0001948 IDA
    GTP binding GO:0005525 ISS
Biological Process
    Rab protein signal transduction GO:0032482 IBA
    vesicle-mediated transport GO:0016192 NAS
    body fluid secretion GO:0007589 IMP
    apical protein localization GO:0045176 IDA
    metabolic process GO:0008152 NAS
    endocytic recycling GO:0032456 ISS
    regulation of protein localization GO:0032880 ISO
    fibroblast growth factor receptor signaling pathway GO:0008543 ISS
    phagolysosome assembly involved in apoptotic cell clearance GO:0090387 IBA
    intracellular transport GO:0046907 NAS
    intracellular protein transport GO:0006886 IBA
    defense response to bacterium GO:0042742 IEA
    Golgi to endosome transport GO:0006895 TAS
Subcellular Localization
    late endosome GO:0005770 IDA
    early endosome GO:0005769 IDA
    lysosome GO:0005764 IDA
    nuclear outer membrane-endoplasmic reticulum membrane network GO:0042175 IDA
    alveolar lamellar body GO:0097208 IDA
    intracellular membrane-bounded organelle GO:0043231 ISO
    intracellular GO:0005622 ISO
    extracellular exosome GO:0070062 ISO
    transport vesicle GO:0030133 IDA
    cell GO:0005623 ISO
    rough endoplasmic reticulum GO:0005791 IDA
    Golgi stack GO:0005795 IDA
    phagocytic vesicle GO:0045335 ISS
    apical plasma membrane GO:0016324 IDA
    cytosol GO:0005829 IDA
    early endosome membrane GO:0031901 IEA
    phagocytic vesicle membrane GO:0030670 IEA
    trans-Golgi network transport vesicle GO:0030140 IDA
    lysosomal membrane GO:0005765 ISO
    Golgi membrane GO:0000139 IEA
    primary cilium GO:0072372 ISO
    recycling endosome GO:0055037 ISS
    cytoplasm GO:0005737 ISO
    cytoplasmic vesicle membrane GO:0030659 TAS
    trans-Golgi network GO:0005802 IEA
    perinuclear region of cytoplasm GO:0048471 IDA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified Rab14 in exosomes
1
Experiment ID 35
MISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix|CD81|CD63
EV Enriched markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
2
Experiment ID 90
MISEV standards
✔
EM
EV Biophysical techniques
✔
HSC70|HSP90|TSG101|MHCI
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 94
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 95
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
5
Experiment ID 99
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
6
Experiment ID 100
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
7
Experiment ID 101
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Rab14
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rab14 is involved
PathwayEvidenceSource
Translocation of GLUT4 to the plasma membrane IEA Reactome





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