Gene description for Dpep1
Gene name dipeptidase 1 (renal)
Gene symbol Dpep1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Dpep1
ExoCarta ExoCarta_94199
Vesiclepedia VP_94199
Entrez Gene 94199
UniProt P31430  
 Dpep1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Dpep1
Molecular Function
    zinc ion binding GO:0008270 ISO
    zinc ion binding GO:0008270 ISS
    beta-lactamase activity GO:0008800 ISO
    beta-lactamase activity GO:0008800 ISS
    dipeptidase activity GO:0016805 ISO
    dipeptidase activity GO:0016805 ISS
    dipeptidase activity GO:0016805 TAS
    GPI anchor binding GO:0034235 ISO
    GPI anchor binding GO:0034235 ISS
    identical protein binding GO:0042802 ISO
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 ISO
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 ISS
    metallodipeptidase activity GO:0070573 ISO
    metallodipeptidase activity GO:0070573 ISS
    modified amino acid binding GO:0072341 ISO
    modified amino acid binding GO:0072341 ISS
Biological Process
    proteolysis GO:0006508 IEA
    leukotriene metabolic process GO:0006691 ISO
    leukotriene metabolic process GO:0006691 ISS
    glutathione catabolic process GO:0006751 ISO
    glutathione catabolic process GO:0006751 ISS
    inflammatory response GO:0006954 ISO
    antibiotic metabolic process GO:0016999 ISO
    antibiotic metabolic process GO:0016999 ISS
    negative regulation of cell migration GO:0030336 ISO
    negative regulation of cell migration GO:0030336 ISS
    neutrophil chemotaxis GO:0030593 ISO
    cellular response to insulin stimulus GO:0032869 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    negative regulation of apoptotic process GO:0043066 ISS
    homocysteine metabolic process GO:0050667 ISO
    homocysteine metabolic process GO:0050667 ISS
    cellular response to calcium ion GO:0071277 ISO
    cellular response to calcium ion GO:0071277 ISS
    cellular response to xenobiotic stimulus GO:0071466 ISO
    cellular response to xenobiotic stimulus GO:0071466 ISS
    cellular response to nitric oxide GO:0071732 ISO
    cellular response to nitric oxide GO:0071732 ISS
    leukotriene D4 catabolic process GO:1901749 ISO
    leukotriene D4 catabolic process GO:1901749 ISS
    negative regulation of cysteine-type endopeptidase activity GO:2000117 ISO
    negative regulation of cysteine-type endopeptidase activity GO:2000117 ISS
Subcellular Localization
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISS
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    endoplasmic reticulum membrane GO:0005789 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    apical plasma membrane GO:0016324 IEA
    cell junction GO:0030054 IEA
    cell junction GO:0030054 ISO
    microvillus membrane GO:0031528 IEA
    apical part of cell GO:0045177 ISO
    apical part of cell GO:0045177 ISS
    side of membrane GO:0098552 IEA
 Experiment description of studies that identified Dpep1 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Dpep1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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