Gene description for Dpep1
Gene name dipeptidase 1 (renal)
Gene symbol Dpep1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Dpep1
ExoCarta ExoCarta_94199
Entrez Gene 94199
UniProt P31430  
 Dpep1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Dpep1
Molecular Function
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 ISS
    zinc ion binding GO:0008270 ISS
    metallodipeptidase activity GO:0070573 ISS
    GPI anchor binding GO:0034235 ISS
    dipeptidyl-peptidase activity GO:0008239 IEA
    dipeptidase activity GO:0016805 TAS
    modified amino acid binding GO:0072341 ISS
Biological Process
    negative regulation of apoptotic process GO:0043066 ISS
    cellular response to nitric oxide GO:0071732 ISS
    homocysteine metabolic process GO:0050667 ISS
    cellular response to calcium ion GO:0071277 ISS
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 ISS
    negative regulation of cell migration GO:0030336 ISS
    proteolysis GO:0006508 IEA
    cellular response to drug GO:0035690 ISS
    antibiotic metabolic process GO:0016999 ISS
Subcellular Localization
    plasma membrane GO:0005886 ISS
    microvillus membrane GO:0031528 IEA
    anchored component of membrane GO:0031225 IEA
    apical plasma membrane GO:0016324 IEA
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 ISS
    nucleus GO:0005634 ISO
    apical part of cell GO:0045177 ISS
    cell junction GO:0030054 ISO
 Experiment description of studies that identified Dpep1 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Dpep1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dpep1 is involved
PathwayEvidenceSource
Aflatoxin activation and detoxification IEA Reactome
Synthesis of Leukotrienes (LT) and Eoxins (EX) IEA Reactome





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