Gene description for Ugt1a6a
Gene name UDP glucuronosyltransferase 1 family, polypeptide A6A
Gene symbol Ugt1a6a
Other names/aliases UDPGT
UDPGT 1-6
UGT1-06
UGT1.6
Ugt1a6
Ugt1a7
Species Mus musculus
 Database cross references - Ugt1a6a
ExoCarta ExoCarta_94284
Entrez Gene 94284
UniProt Q64435  
 Ugt1a6a identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ugt1a6a
Molecular Function
    protein homodimerization activity GO:0042803 ISO
    glucuronosyltransferase activity GO:0015020 ISO
    transferase activity GO:0016740 IEA
    transferase activity, transferring hexosyl groups GO:0016758 IEA
    protein heterodimerization activity GO:0046982 ISO
    protein complex binding GO:0032403 ISO
    transferase activity, transferring glycosyl groups GO:0016757 IEA
    enzyme binding GO:0019899 ISO
Biological Process
    flavonoid glucuronidation GO:0052696 IBA
    xenobiotic glucuronidation GO:0052697 IBA
    glucuronate metabolic process GO:0019585 ISO
    metabolic process GO:0008152 IEA
    flavonoid biosynthetic process GO:0009813 IBA
    cellular response to hormone stimulus GO:0032870 IBA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    integral component of membrane GO:0016021 IEA
    protein complex GO:0043234 ISO
    mitochondrial inner membrane GO:0005743 IDA
    endoplasmic reticulum GO:0005783 ISO
    membrane GO:0016020 IEA
    endoplasmic reticulum membrane GO:0005789 IBA
 Experiment description of studies that identified Ugt1a6a in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ugt1a6a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ugt1a6a is involved
PathwayEvidenceSource
Glucuronidation IEA Reactome





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