Gene description for Acsl5
Gene name acyl-CoA synthetase long-chain family member 5
Gene symbol Acsl5
Other names/aliases Acs5
Facl5
Species Rattus norvegicus
 Database cross references - Acsl5
ExoCarta ExoCarta_94340
Vesiclepedia VP_94340
Entrez Gene 94340
UniProt O88813  
 Acsl5 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Acsl5
Molecular Function
    long-chain fatty acid-CoA ligase activity GO:0004467 IDA
    long-chain fatty acid-CoA ligase activity GO:0004467 IEA
    long-chain fatty acid-CoA ligase activity GO:0004467 IMP
    long-chain fatty acid-CoA ligase activity GO:0004467 ISO
    ATP binding GO:0005524 IEA
    arachidonate-CoA ligase activity GO:0047676 IBA
    arachidonate-CoA ligase activity GO:0047676 IDA
    oleoyl-CoA ligase activity GO:0090434 IEA
    oleoyl-CoA ligase activity GO:0090434 ISO
    oleoyl-CoA ligase activity GO:0090434 ISS
Biological Process
    long-chain fatty acid metabolic process GO:0001676 IDA
    long-chain fatty acid metabolic process GO:0001676 IEA
    long-chain fatty acid metabolic process GO:0001676 IMP
    long-chain fatty acid metabolic process GO:0001676 ISO
    fatty acid metabolic process GO:0006631 TAS
    response to nutrient GO:0007584 IEP
    lipid biosynthetic process GO:0008610 IEA
    phospholipid biosynthetic process GO:0008654 IGI
    response to sucrose GO:0009744 IEP
    response to glucose GO:0009749 IEP
    positive regulation of long-chain fatty acid import across plasma membrane GO:0010747 IBA
    positive regulation of long-chain fatty acid import across plasma membrane GO:0010747 IDA
    positive regulation of triglyceride biosynthetic process GO:0010867 IDA
    fatty acid transport GO:0015908 IGI
    positive regulation of fatty acid beta-oxidation GO:0032000 IGI
    cellular response to insulin stimulus GO:0032869 IEP
    long-chain fatty-acyl-CoA biosynthetic process GO:0035338 IBA
    long-chain fatty-acyl-CoA biosynthetic process GO:0035338 IGI
    response to cholesterol GO:0070723 IEP
    regulation of extrinsic apoptotic signaling pathway GO:2001236 ISO
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 ISO
    mitochondrial outer membrane GO:0005741 IEA
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    membrane GO:0016020 IBA
 Experiment description of studies that identified Acsl5 in sEVs
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Acsl5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here