Gene description for Acsl5
Gene name acyl-CoA synthetase long-chain family member 5
Gene symbol Acsl5
Other names/aliases Acs5
Facl5
Species Rattus norvegicus
 Database cross references - Acsl5
ExoCarta ExoCarta_94340
Entrez Gene 94340
UniProt O88813  
 Acsl5 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Acsl5
Molecular Function
    catalytic activity GO:0003824 IEA
    ATP binding GO:0005524 IEA
    long-chain fatty acid-CoA ligase activity GO:0004467 ISO
Biological Process
    fatty acid metabolic process GO:0006631 TAS
    regulation of extrinsic apoptotic signaling pathway GO:2001236 ISO
    response to cholesterol GO:0070723 IEP
    response to glucose GO:0009749 IEP
    response to nutrient GO:0007584 IEP
    metabolic process GO:0008152 IEA
    response to sucrose GO:0009744 IEP
    phospholipid biosynthetic process GO:0008654 IGI
    positive regulation of fatty acid beta-oxidation GO:0032000 IGI
    fatty acid transport GO:0015908 IGI
    long-chain fatty acid metabolic process GO:0001676 ISO
    positive regulation of plasma membrane long-chain fatty acid transport GO:0010747 IDA
    cellular response to insulin stimulus GO:0032869 IEP
    positive regulation of triglyceride biosynthetic process GO:0010867 IDA
Subcellular Localization
    membrane GO:0016020 ISO
    nucleolus GO:0005730 ISO
    endoplasmic reticulum membrane GO:0005789 IEA
    nucleus GO:0005634 ISO
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum GO:0005783 ISO
    mitochondrion GO:0005739 ISO
    mitochondrial outer membrane GO:0005741 IEA
    mitochondrial inner membrane GO:0005743 ISO
 Experiment description of studies that identified Acsl5 in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Acsl5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Acsl5 is involved
No pathways found





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