Gene description for Loxl2
Gene name lysyl oxidase-like 2
Gene symbol Loxl2
Other names/aliases 1110004B06Rik
4930526G11Rik
9430067E15Rik
Species Mus musculus
 Database cross references - Loxl2
ExoCarta ExoCarta_94352
Entrez Gene 94352
UniProt P58022  
 Loxl2 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Loxl2
Molecular Function
    copper ion binding GO:0005507 IEA
    oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016641 IEA
    methylated histone binding GO:0035064 ISO
    oligosaccharide binding GO:0070492 ISO
    chromatin binding GO:0003682 ISO
    protein-lysine 6-oxidase activity GO:0004720 ISO
    transcription corepressor activity GO:0003714 ISO
    scavenger receptor activity GO:0005044 IEA
    oxidoreductase activity GO:0016491 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    endothelial cell proliferation GO:0001935 ISO
    oxidation-reduction process GO:0055114 ISO
    response to copper ion GO:0046688 ISO
    chromatin modification GO:0016568 IEA
    positive regulation of chondrocyte differentiation GO:0032332 IMP
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    endothelial cell migration GO:0043542 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    collagen fibril organization GO:0030199 ISO
    epithelial to mesenchymal transition GO:0001837 ISO
    cellular protein modification process GO:0006464 ISO
    histone modification GO:0016570 ISO
    response to hypoxia GO:0001666 IDA
    protein deamination GO:0018277 ISO
    transcription, DNA-templated GO:0006351 IEA
    sprouting angiogenesis GO:0002040 ISO
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    nucleus GO:0005634 ISO
    chromosome GO:0005694 IEA
    extracellular space GO:0005615 ISO
    membrane GO:0016020 IEA
    basement membrane GO:0005604 ISO
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified Loxl2 in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Loxl2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Loxl2 is involved
No pathways found





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