Gene description for Hist2h3c2
Gene name histone cluster 2, H3c2
Gene symbol Hist2h3c2
Other names/aliases H3-614
H3.2-614
Hist2h3c2-ps
Hist2h3ca1
M32461
Species Mus musculus
 Database cross references - Hist2h3c2
ExoCarta ExoCarta_97114
Entrez Gene 97114
UniProt P84228  
 Hist2h3c2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
Oligodendrocytes 21136642    
 Gene ontology annotations for Hist2h3c2
Molecular Function
    histone binding GO:0042393 ISO
Biological Process
    regulation of gene silencing GO:0060968 ISO
    DNA replication-dependent nucleosome assembly GO:0006335 ISO
    positive regulation of defense response to virus by host GO:0002230 ISO
    protein heterotetramerization GO:0051290 ISO
    nucleosome assembly GO:0006334 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    nuclear chromosome GO:0000228 ISO
    nucleosome GO:0000786 ISO
    nucleus GO:0005634 ISO
    nuclear nucleosome GO:0000788 ISO
    membrane GO:0016020 ISO
    protein complex GO:0043234 ISO
 Experiment description of studies that identified Hist2h3c2 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 33
ISEV standards
✔
EM|IEM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Hist2h3c2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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