Gene description for Atp1a2
Gene name ATPase, Na+/K+ transporting, alpha 2 polypeptide
Gene symbol Atp1a2
Other names/aliases AW060654
Atpa-3
mKIAA0778
Species Mus musculus
 Database cross references - Atp1a2
ExoCarta ExoCarta_98660
Entrez Gene 98660
UniProt Q6PIE5  
 Atp1a2 identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Atp1a2
Molecular Function
    ATP binding GO:0005524 ISO
    nucleotide binding GO:0000166 IEA
    metal ion binding GO:0046872 IEA
    chaperone binding GO:0051087 ISO
    hydrolase activity GO:0016787 IEA
    protein binding GO:0005515 IPI
    steroid hormone binding GO:1990239 ISO
    sodium:potassium-exchanging ATPase activity GO:0005391 ISO
    cation-transporting ATPase activity GO:0019829 ISO
Biological Process
    cellular sodium ion homeostasis GO:0006883 ISO
    potassium ion transport GO:0006813 ISO
    response to glycoside GO:1903416 ISO
    regulation of vasoconstriction GO:0019229 IMP
    ATP hydrolysis coupled proton transport GO:0015991 ISO
    regulation of smooth muscle contraction GO:0006940 IMP
    cellular response to mechanical stimulus GO:0071260 ISO
    negative regulation of striated muscle contraction GO:0045988 IMP
    visual learning GO:0008542 IMP
    regulation of blood pressure GO:0008217 IGI
    cellular response to steroid hormone stimulus GO:0071383 ISO
    regulation of striated muscle contraction GO:0006942 IMP
    adult locomotory behavior GO:0008344 IMP
    regulation of respiratory gaseous exchange by neurological system process GO:0002087 IMP
    transport GO:0006810 IEA
    regulation of the force of heart contraction GO:0002026 IMP
    sodium ion transport GO:0006814 ISO
    response to nicotine GO:0035094 ISO
    negative regulation of cytosolic calcium ion concentration GO:0051481 IMP
    potassium ion import GO:0010107 ISO
    ion transport GO:0006811 IEA
    locomotion GO:0040011 IMP
    negative regulation of calcium ion transmembrane transport GO:1903170 ISO
    neurotransmitter uptake GO:0001504 IMP
    negative regulation of heart contraction GO:0045822 IMP
    sodium ion export from cell GO:0036376 ISO
    negative regulation of calcium:sodium antiporter activity GO:1903280 ISO
    regulation of muscle contraction GO:0006937 IMP
    cellular potassium ion homeostasis GO:0030007 ISO
    regulation of cardiac muscle cell contraction GO:0086004 ISO
Subcellular Localization
    synapse GO:0045202 ISO
    intercalated disc GO:0014704 ISO
    sodium:potassium-exchanging ATPase complex GO:0005890 ISO
    neuron projection GO:0043005 ISO
    T-tubule GO:0030315 ISO
    cytosol GO:0005829 IMP
    membrane GO:0016020 IEA
    cytoplasm GO:0005737 ISO
    cell GO:0005623 IMP
    caveola GO:0005901 ISO
    endosome GO:0005768 ISO
    sarcolemma GO:0042383 ISO
    dendritic spine GO:0043197 ISO
    integral component of membrane GO:0016021 IEA
    myelin sheath GO:0043209 IDA
    extracellular vesicle GO:1903561 ISO
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Atp1a2 in exosomes
1
Experiment ID 33
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Atp1a2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atp1a2 is involved
PathwayEvidenceSource
Ion transport by P-type ATPases IEA Reactome





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