Gene description for KIF14
Gene name kinesin family member 14
Gene symbol KIF14
Other names/aliases MKS12
Species Homo sapiens
 Database cross references - KIF14
ExoCarta ExoCarta_9928
Entrez Gene 9928
HGNC 19181
MIM 611279
UniProt Q15058  
 KIF14 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for KIF14
Molecular Function
    PDZ domain binding GO:0030165 IDA
    ATPase activity GO:0016887 ISS
    microtubule motor activity GO:0003777 IBA
    protein kinase binding GO:0019901 IPI
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 ISS
    ATP binding GO:0005524 ISS
    ATP-dependent microtubule motor activity, plus-end-directed GO:0008574 ISS
    tubulin binding GO:0015631 ISS
Biological Process
    microtubule-based movement GO:0007018 IBA
    cell proliferation in forebrain GO:0021846 ISS
    response to docetaxel trihydrate GO:1902519 IMP
    regulation of neuron apoptotic process GO:0043523 ISS
    negative regulation of apoptotic process GO:0043066 IMP
    regulation of cell migration GO:0030334 IMP
    activation of protein kinase activity GO:0032147 IMP
    cerebellar cortex development GO:0021695 ISS
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IMP
    cytoskeleton-dependent intracellular transport GO:0030705 IBA
    microtubule depolymerization GO:0007019 ISS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IMP
    positive regulation of cytokinesis GO:0032467 IMP
    cerebellar Purkinje cell layer structural organization GO:0021693 ISS
    hippocampus development GO:0021766 ISS
    positive regulation of cell proliferation GO:0008284 IMP
    olfactory bulb development GO:0021772 ISS
    negative regulation of neuron apoptotic process GO:0043524 ISS
    cerebral cortex development GO:0021987 ISS
    regulation of G1/S transition of mitotic cell cycle GO:2000045 IMP
    substrate adhesion-dependent cell spreading GO:0034446 IDA
    mitotic metaphase plate congression GO:0007080 IMP
    regulation of G2/M transition of mitotic cell cycle GO:0010389 IMP
    cerebellar granular layer structural organization GO:0021685 ISS
    small GTPase mediated signal transduction GO:0007264 TAS
    negative regulation of integrin activation GO:0033624 IMP
    mitotic cell cycle process GO:1903047 IMP
    regulation of myelination GO:0031641 ISS
    regulation of cell growth GO:0001558 IMP
    establishment of protein localization GO:0045184 IDA
    regulation of Rap protein signal transduction GO:0032487 IMP
    regulation of cell adhesion GO:0030155 IMP
Subcellular Localization
    microtubule GO:0005874 IDA
    membrane GO:0016020 IDA
    cytosol GO:0005829 TAS
    spindle midzone GO:0051233 IDA
    nucleus GO:0005634 IEA
    kinesin complex GO:0005871 IBA
    midbody GO:0030496 IDA
    plasma membrane GO:0005886 IPI
 Experiment description of studies that identified KIF14 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for KIF14
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which KIF14 is involved
PathwayEvidenceSource
RHO GTPases activate CIT TAS Reactome





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