miRNA description for let-7i
miRNA accession let-7i
Species Homo sapiens
 let-7i identified in sEVs derived from the following tissue/cell type
Dendritic cells 21505438    
Endothelial cells 26027894    
Plasma 29295981    
Plasma 29295981    
Plasma 29295981    
Plasma 29295981    
Plasma 29295981    
Plasma 29295981    
Plasma 29295981    
Plasma 29295981    
Serum 18589210    
Stomach cancer cells 20949044    
Stomach cancer cells 20949044    
T cells 21505438    
 Experiment description of studies that identified let-7i in sEVs
1
Experiment ID 117
Identified molecule miRNA
Identification method
Human miRNA Microarray Kit   
PubMed ID 21505438    
Organism Homo sapiens
Experiment description Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells.
Authors "Mittelbrunn M, Gutierrez-Vázquez C, Villarroya-Beltri C, González S, Sánchez-Cabo F, González MÁ, Bernad A, Sánchez-Madrid F."
Journal name NATCOM
Publication year 2011
Sample Dendritic cells
Sample name Dendritic cells
Molecules identified in the study Protein
miRNA
Methods used in the study Mass spectrometry
Microarray
2
Experiment ID 226
Identified molecule miRNA
Identification method
Small RNA sequencing (Illumina HiSeq 2000 (Solexa)   
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
3
Experiment ID 614
Identified molecule miRNA
Identification method
RT-qPCR   
PubMed ID 29295981    
Organism Homo sapiens
Experiment description Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
Authors "Kimura K, Hohjoh H, Fukuoka M, Sato W, Oki S, Tomi C, Yamaguchi H, Kondo T, Takahashi R, Yamamura T."
Journal name Nat Commun
Publication year 2018
Sample Plasma
Sample name Healthy controls
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Microarray
RT-qPCR
4
Experiment ID 615
Identified molecule miRNA
Identification method
RT-qPCR   
PubMed ID 29295981    
Organism Homo sapiens
Experiment description Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
Authors "Kimura K, Hohjoh H, Fukuoka M, Sato W, Oki S, Tomi C, Yamaguchi H, Kondo T, Takahashi R, Yamamura T."
Journal name Nat Commun
Publication year 2018
Sample Plasma
Sample name Multiple sclerosis
Molecules identified in the study miRNA
Methods used in the study Microarray
RT-qPCR
5
Experiment ID 616
Identified molecule miRNA
Identification method
RT-qPCR   
PubMed ID 29295981    
Organism Homo sapiens
Experiment description Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
Authors "Kimura K, Hohjoh H, Fukuoka M, Sato W, Oki S, Tomi C, Yamaguchi H, Kondo T, Takahashi R, Yamamura T."
Journal name Nat Commun
Publication year 2018
Sample Plasma
Sample name Relapsing-remitting multiple sclerosis
Molecules identified in the study miRNA
Methods used in the study RT-qPCR
6
Experiment ID 617
Identified molecule miRNA
Identification method
RT-qPCR   
PubMed ID 29295981    
Organism Homo sapiens
Experiment description Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
Authors "Kimura K, Hohjoh H, Fukuoka M, Sato W, Oki S, Tomi C, Yamaguchi H, Kondo T, Takahashi R, Yamamura T."
Journal name Nat Commun
Publication year 2018
Sample Plasma
Sample name Secondary-progressive multiple sclerosis
Molecules identified in the study miRNA
Methods used in the study RT-qPCR
7
Experiment ID 618
Identified molecule miRNA
Identification method
RT-qPCR   
PubMed ID 29295981    
Organism Homo sapiens
Experiment description Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
Authors "Kimura K, Hohjoh H, Fukuoka M, Sato W, Oki S, Tomi C, Yamaguchi H, Kondo T, Takahashi R, Yamamura T."
Journal name Nat Commun
Publication year 2018
Sample Plasma
Sample name Multiple sclerosis in remission phase
Molecules identified in the study miRNA
Methods used in the study RT-qPCR
8
Experiment ID 619
Identified molecule miRNA
Identification method
RT-qPCR   
PubMed ID 29295981    
Organism Homo sapiens
Experiment description Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
Authors "Kimura K, Hohjoh H, Fukuoka M, Sato W, Oki S, Tomi C, Yamaguchi H, Kondo T, Takahashi R, Yamamura T."
Journal name Nat Commun
Publication year 2018
Sample Plasma
Sample name Multiple sclerosis in relapse phase
Molecules identified in the study miRNA
Methods used in the study RT-qPCR
9
Experiment ID 620
Identified molecule miRNA
Identification method
RT-qPCR   
PubMed ID 29295981    
Organism Homo sapiens
Experiment description Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
Authors "Kimura K, Hohjoh H, Fukuoka M, Sato W, Oki S, Tomi C, Yamaguchi H, Kondo T, Takahashi R, Yamamura T."
Journal name Nat Commun
Publication year 2018
Sample Plasma
Sample name Male with multiple sclerosis
Molecules identified in the study miRNA
Methods used in the study RT-qPCR
10
Experiment ID 621
Identified molecule miRNA
Identification method
RT-qPCR   
PubMed ID 29295981    
Organism Homo sapiens
Experiment description Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
Authors "Kimura K, Hohjoh H, Fukuoka M, Sato W, Oki S, Tomi C, Yamaguchi H, Kondo T, Takahashi R, Yamamura T."
Journal name Nat Commun
Publication year 2018
Sample Plasma
Sample name Female with multiple sclerosis
Molecules identified in the study miRNA
Methods used in the study RT-qPCR
11
Experiment ID 45
Identified molecule miRNA
Identification method
467microRNA Array   
PubMed ID 18589210    
Organism Homo sapiens
Experiment description MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
Authors "Taylor DD, Gercel-Taylor C"
Journal name GO
Publication year 2008
Sample Serum
Sample name Serum - Papillary adenocarcinoma of ovary
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
467microRNA Array
12
Experiment ID 88
Identified molecule miRNA
Identification method
Human miRNA Microarray Kit
RT-PCR
  
PubMed ID 20949044    
Organism Homo sapiens
Experiment description Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line
Authors "Ohshima K, Inoue K, Fujiwara A, Hatakeyama K, Kanto K, Watanabe Y, Muramatsu K, Fukuda Y, Ogura S, Yamaguchi K, Mochizuki T."
Journal name PLoS One
Publication year 2010
Sample Stomach cancer cells
Sample name AZ-P7a
Molecules identified in the study Protein
miRNA
Methods used in the study Immunoelectron Microscopy
Western blotting
RT-PCR
Human miRNA Microarray Kit
13
Experiment ID 82
Identified molecule miRNA
Identification method
RT-PCR   
PubMed ID 20949044    
Organism Homo sapiens
Experiment description Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line
Authors "Ohshima K, Inoue K, Fujiwara A, Hatakeyama K, Kanto K, Watanabe Y, Muramatsu K, Fukuda Y, Ogura S, Yamaguchi K, Mochizuki T."
Journal name PLoS One
Publication year 2010
Sample Stomach cancer cells
Sample name AZ-521
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
RT-PCR
Human miRNA Microarray Kit
14
Experiment ID 115
Identified molecule miRNA
Identification method
Human miRNA Microarray Kit   
PubMed ID 21505438    
Organism Homo sapiens
Experiment description Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells.
Authors "Mittelbrunn M, Gutierrez-Vázquez C, Villarroya-Beltri C, González S, Sánchez-Cabo F, González MÁ, Bernad A, Sánchez-Madrid F."
Journal name NATCOM
Publication year 2011
Sample T cells
Sample name J77
Molecules identified in the study Protein
miRNA
Methods used in the study Mass spectrometry
Microarray