miRNA description for miR-21
miRNA accession miR-21
Species Homo sapiens
 miR-21 identified in sEVs derived from the following tissue/cell type
Ascites 21601258    
Breast cancer cells 30918259    
Breast cancer cells 30918259    
Colorectal cancer cells 29472616    
Colorectal cancer cells 29472616    
Colorectal cancer cells 29472616    
Colorectal cancer cells 29472616    
Colorectal cancer cells 29472616    
Colorectal cancer cells 29472616    
Colorectal cancer cells 29472616    
Colorectal cancer cells 29472616    
Colorectal cancer patients 29472616    
Colorectal cancer patients 29472616    
Dendritic cells 21505438    
Malignant ascites 21601258    
Mesenchymal stem cells 25669974    
Pleural effusions 21601258    
Serum 18589210    
T cells 21505438    
 Experiment description of studies that identified miR-21 in sEVs
1
Experiment ID 110
Identified molecule miRNA
Identification method
RT-PCR   
PubMed ID 21601258    
Organism Homo sapiens
Experiment description Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage.
Authors "Rupp AK, Rupp C, Keller S, Brase JC, Ehehalt R, Fogel M, Moldenhauer G, Marme F, Sultmann H, Altevogt P."
Journal name GO
Publication year 2011
Sample Ascites
Sample name Ascites - Liver cirrhosis
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Immunoelctron microscopy
2
Experiment ID 928
Identified molecule miRNA
Identification method
miRNA array   
PubMed ID 30918259    
Organism Homo sapiens
Experiment description Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A
Authors "Im EJ, Lee CH, Moon PG, Rangaswamy GG, Lee B, Lee JM, Lee JC, Jee JG, Bae JS, Kwon TK, Kang KW, Jeong MS, Lee JE, Jung HS, Ro HJ, Jun S, Kang W, Seo SY, Cho YE, Song BJ, Baek MC."
Journal name Nat Commun
Publication year 2019
Sample Breast cancer cells
Sample name MDA-MB-231
Molecules identified in the study miRNA
Methods used in the study miRNA array
3
Experiment ID 929
Identified molecule miRNA
Identification method
miRNA array   
PubMed ID 30918259    
Organism Homo sapiens
Experiment description Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A
Authors "Im EJ, Lee CH, Moon PG, Rangaswamy GG, Lee B, Lee JM, Lee JC, Jee JG, Bae JS, Kwon TK, Kang KW, Jeong MS, Lee JE, Jung HS, Ro HJ, Jun S, Kang W, Seo SY, Cho YE, Song BJ, Baek MC."
Journal name Nat Commun
Publication year 2019
Sample Breast cancer cells
Sample name MDA-MB-231
Molecules identified in the study miRNA
Methods used in the study miRNA array
4
Experiment ID 340
Identified molecule miRNA
Identification method
miR-chip array   
PubMed ID 29472616    
Organism Homo sapiens
Experiment description Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Authors "Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC."
Journal name Nat Commun
Publication year 2018
Sample Colorectal cancer cells
Sample name HCT116
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
miR-chip array
5
Experiment ID 341
Identified molecule miRNA
Identification method
miR-chip array   
PubMed ID 29472616    
Organism Homo sapiens
Experiment description Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Authors "Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC."
Journal name Nat Commun
Publication year 2018
Sample Colorectal cancer cells
Sample name HCT116
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
miR-chip array
6
Experiment ID 342
Identified molecule miRNA
Identification method
miR-chip array   
PubMed ID 29472616    
Organism Homo sapiens
Experiment description Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Authors "Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC."
Journal name Nat Commun
Publication year 2018
Sample Colorectal cancer cells
Sample name HT29
Molecules identified in the study Protein
miRNA
Methods used in the study Mass spectrometry
miR-chip array
7
Experiment ID 343
Identified molecule miRNA
Identification method
miR-chip array   
PubMed ID 29472616    
Organism Homo sapiens
Experiment description Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Authors "Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC."
Journal name Nat Commun
Publication year 2018
Sample Colorectal cancer cells
Sample name HT29
Molecules identified in the study Protein
miRNA
Methods used in the study Mass spectrometry
miR-chip array
8
Experiment ID 344
Identified molecule miRNA
Identification method
qPCR   
PubMed ID 29472616    
Organism Homo sapiens
Experiment description Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Authors "Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC."
Journal name Nat Commun
Publication year 2018
Sample Colorectal cancer cells
Sample name HCT116 - Fraction 5
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
qPCR
9
Experiment ID 345
Identified molecule miRNA
Identification method
qPCR   
PubMed ID 29472616    
Organism Homo sapiens
Experiment description Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Authors "Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC."
Journal name Nat Commun
Publication year 2018
Sample Colorectal cancer cells
Sample name HCT116 - Fraction 6
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
qPCR
10
Experiment ID 346
Identified molecule miRNA
Identification method
qPCR   
PubMed ID 29472616    
Organism Homo sapiens
Experiment description Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Authors "Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC."
Journal name Nat Commun
Publication year 2018
Sample Colorectal cancer cells
Sample name HCT116 - Fraction 7
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
qPCR
11
Experiment ID 347
Identified molecule miRNA
Identification method
qPCR   
PubMed ID 29472616    
Organism Homo sapiens
Experiment description Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Authors "Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC."
Journal name Nat Commun
Publication year 2018
Sample Colorectal cancer cells
Sample name HCT116 - Fraction 8
Molecules identified in the study miRNA
Methods used in the study qPCR
12
Experiment ID 352
Identified molecule miRNA
Identification method
qPCR   
PubMed ID 29472616    
Organism Homo sapiens
Experiment description Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Authors "Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC."
Journal name Nat Commun
Publication year 2018
Sample Colorectal cancer patients
Sample name Plasma
Molecules identified in the study miRNA
Methods used in the study qPCR
13
Experiment ID 353
Identified molecule miRNA
Identification method
qPCR   
PubMed ID 29472616    
Organism Homo sapiens
Experiment description Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Authors "Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC."
Journal name Nat Commun
Publication year 2018
Sample Colorectal cancer patients
Sample name Plasma
Molecules identified in the study miRNA
Methods used in the study qPCR
14
Experiment ID 117
Identified molecule miRNA
Identification method
Human miRNA Microarray Kit   
PubMed ID 21505438    
Organism Homo sapiens
Experiment description Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells.
Authors "Mittelbrunn M, Gutierrez-Vázquez C, Villarroya-Beltri C, González S, Sánchez-Cabo F, González MÁ, Bernad A, Sánchez-Madrid F."
Journal name NATCOM
Publication year 2011
Sample Dendritic cells
Sample name Dendritic cells
Molecules identified in the study Protein
miRNA
Methods used in the study Mass spectrometry
Microarray
15
Experiment ID 108
Identified molecule miRNA
Identification method
RT-PCR   
PubMed ID 21601258    
Organism Homo sapiens
Experiment description Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage.
Authors "Rupp AK, Rupp C, Keller S, Brase JC, Ehehalt R, Fogel M, Moldenhauer G, Marme F, Sultmann H, Altevogt P."
Journal name GO
Publication year 2011
Sample Malignant ascites
Sample name Malignant ascites - Ovarian cancer
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Immunoelctron microscopy
16
Experiment ID 261
Identified molecule miRNA
Identification method
Next generation sequencing
RT-PCR		   
PubMed ID 25669974    
Organism Homo sapiens
Experiment description "Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins,and metabolites"
Authors "Krishna C. Vallabhaneni1, Patrice Penfornis, Santosh Dhule, Francois Guillonneau, Kristen V. Adams, Yin Yuan Mo, Rui Xu, Yiming Liu, Kounosuke Watabe, Mohan C. Vemuri and Radhika Pochampally"
Journal name Oncotarget
Publication year 2014
Sample Mesenchymal stem cells
Sample name hMSCs
Molecules identified in the study Protein
miRNA
Lipids
Metabolites
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
Sequencing
17
Experiment ID 109
Identified molecule miRNA
Identification method
RT-PCR   
PubMed ID 21601258    
Organism Homo sapiens
Experiment description Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage.
Authors "Rupp AK, Rupp C, Keller S, Brase JC, Ehehalt R, Fogel M, Moldenhauer G, Marme F, Sultmann H, Altevogt P."
Journal name GO
Publication year 2011
Sample Pleural effusions
Sample name Pleural effusions - Breast cancer
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
18
Experiment ID 45
Identified molecule miRNA
Identification method
467microRNA Array   
PubMed ID 18589210    
Organism Homo sapiens
Experiment description MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
Authors "Taylor DD, Gercel-Taylor C"
Journal name GO
Publication year 2008
Sample Serum
Sample name Serum - Papillary adenocarcinoma of ovary
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
467microRNA Array
19
Experiment ID 115
Identified molecule miRNA
Identification method
Human miRNA Microarray Kit   
PubMed ID 21505438    
Organism Homo sapiens
Experiment description Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells.
Authors "Mittelbrunn M, Gutierrez-Vázquez C, Villarroya-Beltri C, González S, Sánchez-Cabo F, González MÁ, Bernad A, Sánchez-Madrid F."
Journal name NATCOM
Publication year 2011
Sample T cells
Sample name J77
Molecules identified in the study Protein
miRNA
Methods used in the study Mass spectrometry
Microarray