 miRNA description for miR-21-5p |
| miRNA accession |
miR-21-5p |
| Species |
Homo sapiens |
| miR-21-5p identified in sEVs derived from the following tissue/cell type |
|
Colorectal cancer cells
|
25330373
|
|
Colorectal cancer cells
|
29472616
|
|
Colorectal cancer cells
|
29472616
|
|
Colorectal cancer cells
|
29472616
|
|
Lung cancer cells
|
34596365
|
|
Lung cancer cells
|
34596365
|
|
Lung cancer cells
|
34596365
|
|
Lung cancer cells
|
34596365
|
|
Mesenchymal stem cells
|
33479185
|
|
Posterior longitudinal ligament
|
35513391
|
|
Posterior longitudinal ligament
|
35513391
|
| Experiment description of studies that identified miR-21-5p in sEVs |
| 1 |
| Experiment ID |
223 |
| Identified molecule |
miRNA
|
| Identification method |
|
| PubMed ID |
25330373
|
| Organism |
Homo sapiens |
| Experiment description |
Deep sequencing of RNA from three different extracellular vesicle (EV) subtypes released from the human LIM1863 colon cancer cell line uncovers distinct miRNA-enrichment signatures |
| Authors |
"Ji H, Chen M, Greening DW, He W, Rai A, Zhang W, Simpson RJ" |
| Journal name |
PLoS One
|
| Publication year |
2014 |
| Sample |
Colorectal cancer cells |
| Sample name |
LIM1863 |
| Molecules identified in the study |
miRNA
Protein |
| Methods used in the study |
RT-PCR
Western blotting |
|
|
| 2 |
| Experiment ID |
339 |
| Identified molecule |
miRNA
|
| Identification method |
|
| PubMed ID |
29472616
|
| Organism |
Homo sapiens |
| Experiment description |
Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 |
| Authors |
"Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC." |
| Journal name |
Nat Commun
|
| Publication year |
2018 |
| Sample |
Colorectal cancer cells |
| Sample name |
HCT116 |
| Molecules identified in the study |
Protein
miRNA |
| Methods used in the study |
Western blotting
miR-chip array |
|
|
| 3 |
| Experiment ID |
340 |
| Identified molecule |
miRNA
|
| Identification method |
|
| PubMed ID |
29472616
|
| Organism |
Homo sapiens |
| Experiment description |
Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 |
| Authors |
"Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC." |
| Journal name |
Nat Commun
|
| Publication year |
2018 |
| Sample |
Colorectal cancer cells |
| Sample name |
HCT116 |
| Molecules identified in the study |
Protein
miRNA |
| Methods used in the study |
Western blotting
miR-chip array |
|
|
| 4 |
| Experiment ID |
341 |
| Identified molecule |
miRNA
|
| Identification method |
|
| PubMed ID |
29472616
|
| Organism |
Homo sapiens |
| Experiment description |
Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 |
| Authors |
"Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC." |
| Journal name |
Nat Commun
|
| Publication year |
2018 |
| Sample |
Colorectal cancer cells |
| Sample name |
HCT116 |
| Molecules identified in the study |
Protein
miRNA |
| Methods used in the study |
Western blotting
miR-chip array |
|
|
| 5 |
| Experiment ID |
1119 |
| Identified molecule |
miRNA
|
| Identification method |
|
| PubMed ID |
34596365
|
| Organism |
Homo sapiens |
| Experiment description |
Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer |
| Authors |
"Donzelli J, Proestler E, Riedel A, Nevermann S, Hertel B, Guenther A, Gattenlöhner S, Savai R, Larsson K, Saul MJ." |
| Journal name |
J Extracell Vesicles
|
| Publication year |
2021 |
| Sample |
Lung cancer cells |
| Sample name |
A549 |
| Molecules identified in the study |
miRNA |
| Methods used in the study |
RT-qPCR |
|
|
| 6 |
| Experiment ID |
1120 |
| Identified molecule |
miRNA
|
| Identification method |
|
| PubMed ID |
34596365
|
| Organism |
Homo sapiens |
| Experiment description |
Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer |
| Authors |
"Donzelli J, Proestler E, Riedel A, Nevermann S, Hertel B, Guenther A, Gattenlöhner S, Savai R, Larsson K, Saul MJ." |
| Journal name |
J Extracell Vesicles
|
| Publication year |
2021 |
| Sample |
Lung cancer cells |
| Sample name |
A549 |
| Molecules identified in the study |
miRNA |
| Methods used in the study |
RT-qPCR |
|
|
| 7 |
| Experiment ID |
1121 |
| Identified molecule |
miRNA
|
| Identification method |
|
| PubMed ID |
34596365
|
| Organism |
Homo sapiens |
| Experiment description |
Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer |
| Authors |
"Donzelli J, Proestler E, Riedel A, Nevermann S, Hertel B, Guenther A, Gattenlöhner S, Savai R, Larsson K, Saul MJ." |
| Journal name |
J Extracell Vesicles
|
| Publication year |
2021 |
| Sample |
Lung cancer cells |
| Sample name |
2106T |
| Molecules identified in the study |
miRNA |
| Methods used in the study |
RT-qPCR |
|
|
| 8 |
| Experiment ID |
1122 |
| Identified molecule |
miRNA
|
| Identification method |
|
| PubMed ID |
34596365
|
| Organism |
Homo sapiens |
| Experiment description |
Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer |
| Authors |
"Donzelli J, Proestler E, Riedel A, Nevermann S, Hertel B, Guenther A, Gattenlöhner S, Savai R, Larsson K, Saul MJ." |
| Journal name |
J Extracell Vesicles
|
| Publication year |
2021 |
| Sample |
Lung cancer cells |
| Sample name |
2106T |
| Molecules identified in the study |
miRNA |
| Methods used in the study |
RT-qPCR |
|
|
| 9 |
| Experiment ID |
372 |
| Identified molecule |
miRNA
|
| Identification method |
|
| PubMed ID |
33479185
|
| Organism |
Homo sapiens |
| Experiment description |
Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke |
| Authors |
"Zhang Z, Zou X, Zhang R, Xie Y, Feng Z, Li F, Han J, Sun H, Ouyang Q, Hua S, Lv B, Hua T, Liu Z, Cai Y, Zou Y, Tang Y, Jiang X." |
| Journal name |
Aging
|
| Publication year |
2021 |
| Sample |
Mesenchymal stem cells |
| Sample name |
hUMSCs |
| Molecules identified in the study |
Protein
miRNA |
| Methods used in the study |
Western blotting
Microarray |
|
|
| 10 |
| Experiment ID |
868 |
| Identified molecule |
miRNA
|
| Identification method |
|
| PubMed ID |
35513391
|
| Organism |
Homo sapiens |
| Experiment description |
Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1 |
| Authors |
"Xu C, Zhang Z, Liu N, Li L, Zhong H, Wang R, Shi Q, Zhang Z, Wei L, Hu B, Zhang H, Shen X, Wang Y, Liu Y, Yuan W." |
| Journal name |
Nat Commun
|
| Publication year |
2022 |
| Sample |
Posterior longitudinal ligament |
| Sample name |
Ossicifation of posterior longitudinal ligament cells |
| Molecules identified in the study |
Protein
miRNA |
| Methods used in the study |
Western blotting
RNA sequencing
qRT-PCR |
|
|
| 11 |
| Experiment ID |
869 |
| Identified molecule |
miRNA
|
| Identification method |
|
| PubMed ID |
35513391
|
| Organism |
Homo sapiens |
| Experiment description |
Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1 |
| Authors |
"Xu C, Zhang Z, Liu N, Li L, Zhong H, Wang R, Shi Q, Zhang Z, Wei L, Hu B, Zhang H, Shen X, Wang Y, Liu Y, Yuan W." |
| Journal name |
Nat Commun
|
| Publication year |
2022 |
| Sample |
Posterior longitudinal ligament |
| Sample name |
Posterior longitudinal ligament cells |
| Molecules identified in the study |
miRNA |
| Methods used in the study |
RNA sequencing
qRT-PCR |
|
|