Gene description for JTB
Gene name jumping translocation breakpoint
Gene symbol JTB
Other names/aliases HJTB
HSPC222
PAR
hJT
Species Homo sapiens
 Database cross references - JTB
ExoCarta ExoCarta_10899
Vesiclepedia VP_10899
Entrez Gene 10899
HGNC 6201
MIM 604671
UniProt O76095  
 JTB identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for JTB
Molecular Function
    protein kinase binding GO:0019901 IDA
Biological Process
    mitotic cell cycle GO:0000278 IMP
    mitotic cytokinesis GO:0000281 IBA
    mitotic cytokinesis GO:0000281 IMP
    apoptotic mitochondrial changes GO:0008637 IEA
    regulation of cell population proliferation GO:0042127 IEA
    positive regulation of protein kinase activity GO:0045860 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IEA
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    spindle GO:0005819 IBA
    spindle GO:0005819 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 TAS
    midbody GO:0030496 IBA
    midbody GO:0030496 IDA
 Experiment description of studies that identified JTB in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for JTB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UTP20 27340
Affinity Capture-MS Homo sapiens
2 FASN 2194
Negative Genetic Homo sapiens
3 TMED10 10972
Affinity Capture-MS Homo sapiens
4 TCEB1 6921
Two-hybrid Homo sapiens
5 RAB1A 5861
Synthetic Lethality Homo sapiens
6 VAPA 9218
Affinity Capture-MS Homo sapiens
7 SACM1L 22908
Affinity Capture-MS Homo sapiens
8 TTC28 23331
Affinity Capture-MS Homo sapiens
9 ZXDC  
Two-hybrid Homo sapiens
10 PIGA  
Affinity Capture-MS Homo sapiens
11 TMEM120A 83862
Affinity Capture-MS Homo sapiens
12 TMEM120B  
Affinity Capture-MS Homo sapiens
13 ATP12A 479
Affinity Capture-MS Homo sapiens
14 GPR107 57720
Affinity Capture-MS Homo sapiens
15 ATRIP  
Affinity Capture-MS Homo sapiens
16 INTS1 26173
Affinity Capture-MS Homo sapiens
17 KIAA1524 57650
Affinity Capture-MS Homo sapiens
18 USP30  
Affinity Capture-MS Homo sapiens
19 APP 351
Reconstituted Complex Homo sapiens
20 APEX1 328
Affinity Capture-RNA Homo sapiens
21 NF1 4763
Negative Genetic Homo sapiens
22 DCUN1D5 84259
Affinity Capture-MS Homo sapiens
23 XPO4 64328
Affinity Capture-MS Homo sapiens
24 AAAS 8086
Affinity Capture-MS Homo sapiens
25 NDC1 55706
Affinity Capture-MS Homo sapiens
26 RDH13  
Affinity Capture-MS Homo sapiens
27 MIPEP  
Affinity Capture-MS Homo sapiens
28 STK11 6794
Negative Genetic Homo sapiens
29 CUX1 1523
Affinity Capture-MS Homo sapiens
30 LOX 4015
Co-fractionation Homo sapiens
31 BRAF  
Affinity Capture-MS Homo sapiens
32 INTS12  
Affinity Capture-MS Homo sapiens
33 STEAP3 55240
Affinity Capture-MS Homo sapiens
34 DNM1L 10059
Affinity Capture-MS Homo sapiens
35 PIGQ  
Affinity Capture-MS Homo sapiens
36 PTAR1 375743
Synthetic Lethality Homo sapiens
View the network image/svg+xml
 Pathways in which JTB is involved
No pathways found





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