Gene description for Braf
Gene name	Braf transforming gene
Gene symbol	Braf
Other names/aliases	9930012E13Rik AA120551 AA387315 AA473386 B-raf Braf-2 Braf2 C230098H17 C87398 D6Ertd631e
Species	Mus musculus
Database cross references - Braf
ExoCarta	ExoCarta_109880
Vesiclepedia	VP_109880
Entrez Gene	109880
UniProt	P28028
Braf identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Braf

Molecular Function     protein kinase activity GO:0004672 IDA     protein kinase activity GO:0004672 ISO     protein serine/threonine kinase activity GO:0004674 ISO     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     MAP kinase kinase activity GO:0004708 IEA     MAP kinase kinase activity GO:0004708 ISO     MAP kinase kinase kinase activity GO:0004709 IBA     MAP kinase kinase kinase activity GO:0004709 IEA     MAP kinase kinase kinase activity GO:0004709 ISO     ribosomal protein S6 kinase activity GO:0004711 IEA     calcium ion binding GO:0005509 IEA     calcium ion binding GO:0005509 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     small GTPase binding GO:0031267 IEA     small GTPase binding GO:0031267 ISO     mitogen-activated protein kinase kinase binding GO:0031434 IEA     mitogen-activated protein kinase kinase binding GO:0031434 ISO     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     protein-containing complex binding GO:0044877 IEA     protein-containing complex binding GO:0044877 ISO     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     scaffold protein binding GO:0097110 IEA     scaffold protein binding GO:0097110 ISO     protein serine kinase activity GO:0106310 IEA     histone H2BS36 kinase activity GO:0140823 IEA     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA Biological Process     MAPK cascade GO:0000165 IBA     MAPK cascade GO:0000165 ISO     myeloid progenitor cell differentiation GO:0002318 IMP     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 IDA     protein phosphorylation GO:0006468 ISO     epidermal growth factor receptor signaling pathway GO:0007173 IEA     epidermal growth factor receptor signaling pathway GO:0007173 ISO     visual learning GO:0008542 IMP     positive regulation of gene expression GO:0010628 IGI     positive regulation of gene expression GO:0010628 ISO     negative regulation of fibroblast migration GO:0010764 IMP     positive regulation of D-glucose transmembrane transport GO:0010828 IEA     positive regulation of D-glucose transmembrane transport GO:0010828 ISO     synaptic vesicle exocytosis GO:0016079 IMP     cell differentiation GO:0030154 IGI     thyroid gland development GO:0030878 IGI     T cell differentiation in thymus GO:0033077 IMP     positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO     substrate adhesion-dependent cell spreading GO:0034446 IMP     somatic stem cell population maintenance GO:0035019 IGI     regulation of cell population proliferation GO:0042127 IGI     negative regulation of apoptotic process GO:0043066 ISO     stress fiber assembly GO:0043149 IMP     CD4-positive, alpha-beta T cell differentiation GO:0043367 IMP     positive T cell selection GO:0043368 IMP     CD4-positive or CD8-positive, alpha-beta T cell lineage commitment GO:0043369 IMP     response to peptide hormone GO:0043434 IEA     response to peptide hormone GO:0043434 ISO     negative regulation of neuron apoptotic process GO:0043524 IMP     negative regulation of neuron apoptotic process GO:0043524 ISO     regulation of T cell differentiation GO:0045580 IMP     alpha-beta T cell differentiation GO:0046632 IMP     thymus development GO:0048538 IGI     regulation of axon regeneration GO:0048679 IGI     positive regulation of axon regeneration GO:0048680 IDA     positive regulation of axonogenesis GO:0050772 IGI     positive regulation of axonogenesis GO:0050772 IMP     T cell receptor signaling pathway GO:0050852 IDA     positive regulation of stress fiber assembly GO:0051496 IGI     positive regulation of stress fiber assembly GO:0051496 IMP     response to cAMP GO:0051591 IEA     response to cAMP GO:0051591 ISO     long-term synaptic potentiation GO:0060291 IMP     head morphogenesis GO:0060323 IMP     face development GO:0060324 IGI     ERK1 and ERK2 cascade GO:0070371 IMP     positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     cellular response to calcium ion GO:0071277 IEA     cellular response to calcium ion GO:0071277 ISO     cellular response to xenobiotic stimulus GO:0071466 IDA     endothelial cell apoptotic process GO:0072577 IMP     establishment of protein localization to membrane GO:0090150 IEA     establishment of protein localization to membrane GO:0090150 ISO     postsynaptic modulation of chemical synaptic transmission GO:0099170 IDA     postsynaptic modulation of chemical synaptic transmission GO:0099170 IMP     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IMP     cellular response to nerve growth factor stimulus GO:1990090 IEA     negative regulation of synaptic vesicle exocytosis GO:2000301 IMP     negative regulation of endothelial cell apoptotic process GO:2000352 IMP Subcellular Localization     nucleus GO:0005634 IEA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 IDA     cytosol GO:0005829 IBA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     neuron projection GO:0043005 IDA     intracellular membrane-bounded organelle GO:0043231 ISO     cell body GO:0044297 IDA     presynapse GO:0098793 IEA     postsynapse GO:0098794 IEA     glutamatergic synapse GO:0098978 IDA     glutamatergic synapse GO:0098978 IMP