Gene description for RABL2A
Gene name RAB, member of RAS oncogene family-like 2A
Gene symbol RABL2A
Other names/aliases -
Species Homo sapiens
 Database cross references - RABL2A
ExoCarta ExoCarta_11159
Vesiclepedia VP_11159
Entrez Gene 11159
HGNC 9799
MIM 605412
UniProt Q9UBK7  
 RABL2A identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RABL2A
Molecular Function
    GTPase activity GO:0003924 IBA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IEA
Biological Process
    intracellular protein transport GO:0006886 IBA
Subcellular Localization
    endomembrane system GO:0012505 IBA
 Experiment description of studies that identified RABL2A in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RABL2A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SPTBN1 6711
Co-fractionation Homo sapiens
2 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
3 SPTAN1 6709
Co-fractionation Homo sapiens
4 PRKY  
Affinity Capture-MS Homo sapiens
5 SMC5 23137
Co-fractionation Homo sapiens
6 SEC23IP 11196
Affinity Capture-MS Homo sapiens
7 CCDC34 91057
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ALMS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 AKAP11 11215
Affinity Capture-MS Homo sapiens
10 VPS13A 23230
Affinity Capture-MS Homo sapiens
11 SLK 9748
Co-fractionation Homo sapiens
12 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
13 MTO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 METTL21B  
Affinity Capture-MS Homo sapiens
15 TTF2 8458
Affinity Capture-MS Homo sapiens
16 TP73  
Affinity Capture-MS Homo sapiens
17 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
18 CEP19  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
19 BRCA2 675
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 RPP25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 POLA1  
Affinity Capture-MS Homo sapiens
22 FHIT 2272
Affinity Capture-MS Homo sapiens
23 IFNA13  
Affinity Capture-MS Homo sapiens
24 CCT8L2  
Affinity Capture-MS Homo sapiens
25 TBC1D9B 23061
Co-fractionation Homo sapiens
26 FGFR1OP  
Affinity Capture-MS Homo sapiens
27 FIGNL1 63979
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RABL2A is involved
No pathways found





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