Gene description for Cntn1
Gene name contactin 1
Gene symbol Cntn1
Other names/aliases AW495098
CNTN
F3cam
Species Mus musculus
 Database cross references - Cntn1
ExoCarta ExoCarta_12805
Vesiclepedia VP_12805
Entrez Gene 12805
UniProt P12960  
 Cntn1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cntn1
Molecular Function
    protein binding GO:0005515 IPI
    carbohydrate binding GO:0030246 IDA
    cell-cell adhesion mediator activity GO:0098632 IBA
Biological Process
    cell adhesion GO:0007155 IEA
    Notch signaling pathway GO:0007219 IEA
    axon guidance GO:0007411 IBA
    brain development GO:0007420 IBA
    locomotory behavior GO:0007626 IMP
    gene expression GO:0010467 IMP
    positive regulation of gene expression GO:0010628 IMP
    positive regulation of sodium ion transport GO:0010765 IMP
    positive regulation of neuron projection development GO:0010976 IGI
    cerebellum development GO:0021549 IMP
    neuron projection development GO:0031175 IGI
    central nervous system myelin formation GO:0032289 IGI
    myelination GO:0042552 IGI
    myelination GO:0042552 IMP
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    cell-cell adhesion GO:0098609 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    axon GO:0030424 IBA
    presynaptic membrane GO:0042734 IDA
    myelin sheath GO:0043209 HDA
    synapse GO:0045202 IDA
    postsynaptic membrane GO:0045211 IDA
    side of membrane GO:0098552 IEA
    glutamatergic synapse GO:0098978 IDA
 Experiment description of studies that identified Cntn1 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cntn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Uqcrh  
Co-fractionation Mus musculus
2 Cox6b1  
Co-fractionation Mus musculus
3 SNCA 6622
Affinity Capture-MS Homo sapiens
4 Fmr1  
Affinity Capture-MS Mus musculus
5 App 11820
Affinity Capture-MS Mus musculus
6 Kctd13  
Affinity Capture-MS Mus musculus
7 Syp  
Co-fractionation Mus musculus
8 Shank3  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
9 Dlg4  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
10 Mapt  
Affinity Capture-MS Mus musculus
11 Prnp 19122
Affinity Capture-MS Mus musculus
12 Snap25 20614
Co-fractionation Mus musculus
13 Gnao1 14681
Co-fractionation Mus musculus
14 Slc6a1  
Co-fractionation Mus musculus
15 Cntnap2  
Reconstituted Complex Mus musculus
16 Tnr  
Co-fractionation Mus musculus
17 Tnc 21923
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Cntn1 is involved
No pathways found





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