Gene description for App
Gene name amyloid beta (A4) precursor protein
Gene symbol App
Other names/aliases Abeta
Abpp
Adap
Ag
Cvap
E030013M08Rik
betaApp
Species Mus musculus
 Database cross references - App
ExoCarta ExoCarta_11820
Vesiclepedia VP_11820
Entrez Gene 11820
UniProt P12023  
 App identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
Mast cells 17486113    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for App
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    G protein-coupled receptor binding GO:0001664 ISO
    chromatin binding GO:0003682 ISO
    serine-type endopeptidase inhibitor activity GO:0004867 IEA
    serine-type endopeptidase inhibitor activity GO:0004867 ISO
    signaling receptor binding GO:0005102 IBA
    signaling receptor binding GO:0005102 ISO
    frizzled binding GO:0005109 ISO
    insulin receptor binding GO:0005158 ISO
    integrin binding GO:0005178 ISO
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IEA
    peptidase activator activity GO:0016504 ISO
    enzyme binding GO:0019899 ISO
    protein kinase binding GO:0019901 IPI
    protein domain specific binding GO:0019904 IDA
    signaling receptor activator activity GO:0030546 IBA
    signaling receptor activator activity GO:0030546 IDA
    signaling receptor activator activity GO:0030546 ISO
    acetylcholine receptor binding GO:0033130 ISO
    apolipoprotein binding GO:0034185 ISO
    chemoattractant activity GO:0042056 ISO
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    heparan sulfate proteoglycan binding GO:0043395 ISO
    ephrin receptor binding GO:0046875 ISO
    transition metal ion binding GO:0046914 IEA
    protein heterodimerization activity GO:0046982 ISO
    receptor ligand activity GO:0048018 IEA
    receptor ligand activity GO:0048018 ISO
    low-density lipoprotein particle receptor binding GO:0050750 IPI
    RAGE receptor binding GO:0050786 ISO
    protein-folding chaperone binding GO:0051087 ISO
    PTB domain binding GO:0051425 IEA
    PTB domain binding GO:0051425 ISO
    growth factor receptor binding GO:0070851 ISO
    protein serine/threonine kinase binding GO:0120283 IEA
    protein serine/threonine kinase binding GO:0120283 ISO
Biological Process
    G2/M transition of mitotic cell cycle GO:0000086 IMP
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    mitotic cell cycle GO:0000278 IMP
    microglial cell activation GO:0001774 IEA
    microglial cell activation GO:0001774 ISO
    response to yeast GO:0001878 ISO
    positive regulation of protein phosphorylation GO:0001934 ISO
    suckling behavior GO:0001967 IGI
    astrocyte activation involved in immune response GO:0002265 IEA
    astrocyte activation involved in immune response GO:0002265 ISO
    regulation of transcription by RNA polymerase II GO:0006357 ISO
    regulation of translation GO:0006417 IDA
    protein phosphorylation GO:0006468 IMP
    intracellular copper ion homeostasis GO:0006878 IGI
    intracellular copper ion homeostasis GO:0006878 IMP
    endocytosis GO:0006897 IMP
    response to oxidative stress GO:0006979 IGI
    cell adhesion GO:0007155 IEA
    regulation of epidermal growth factor-activated receptor activity GO:0007176 IGI
    G protein-coupled receptor signaling pathway GO:0007186 ISO
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 ISO
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 ISO
    Notch signaling pathway GO:0007219 IEA
    axonogenesis GO:0007409 IBA
    axonogenesis GO:0007409 IMP
    central nervous system development GO:0007417 IBA
    learning or memory GO:0007611 ISO
    learning GO:0007612 ISO
    memory GO:0007613 ISO
    memory GO:0007613 TAS
    mating behavior GO:0007617 IGI
    locomotory behavior GO:0007626 IGI
    axo-dendritic transport GO:0008088 IGI
    axo-dendritic transport GO:0008088 IMP
    axo-dendritic transport GO:0008088 IMP
    cholesterol metabolic process GO:0008203 IGI
    cholesterol metabolic process GO:0008203 IMP
    negative regulation of cell population proliferation GO:0008285 IEA
    negative regulation of cell population proliferation GO:0008285 ISO
    associative learning GO:0008306 ISO
    adult locomotory behavior GO:0008344 IMP
    visual learning GO:0008542 IMP
    gene expression GO:0010467 IMP
    regulation of gene expression GO:0010468 IDA
    regulation of gene expression GO:0010468 ISO
    regulation of gene expression GO:0010468 ISO
    positive regulation of gene expression GO:0010628 ISO
    negative regulation of gene expression GO:0010629 IEA
    negative regulation of gene expression GO:0010629 ISO
    positive regulation of protein kinase A signaling GO:0010739 ISO
    positive regulation of peptidyl-threonine phosphorylation GO:0010800 ISO
    positive regulation of G2/M transition of mitotic cell cycle GO:0010971 IMP
    microglia development GO:0014005 IEA
    microglia development GO:0014005 ISO
    axon midline choice point recognition GO:0016199 IMP
    neuron remodeling GO:0016322 IMP
    dendrite development GO:0016358 IGI
    dendrite development GO:0016358 IMP
    calcium-mediated signaling GO:0019722 ISO
    antibacterial humoral response GO:0019731 ISO
    antifungal humoral response GO:0019732 ISO
    neuron differentiation GO:0030182 IDA
    neuron differentiation GO:0030182 IGI
    extracellular matrix organization GO:0030198 IGI
    forebrain development GO:0030900 IGI
    forebrain development GO:0030900 IMP
    neuron projection development GO:0031175 IDA
    phospholipase D-activating G protein-coupled receptor signaling pathway GO:0031583 ISO
    positive regulation of chemokine production GO:0032722 IEA
    positive regulation of chemokine production GO:0032722 ISO
    positive regulation of type II interferon production GO:0032729 ISO
    positive regulation of interleukin-1 beta production GO:0032731 IEA
    positive regulation of interleukin-1 beta production GO:0032731 ISO
    positive regulation of interleukin-6 production GO:0032755 IEA
    positive regulation of interleukin-6 production GO:0032755 ISO
    positive regulation of tumor necrosis factor production GO:0032760 IEA
    positive regulation of tumor necrosis factor production GO:0032760 IGI
    positive regulation of tumor necrosis factor production GO:0032760 ISO
    positive regulation of superoxide anion generation GO:0032930 ISO
    positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO
    regulation of toll-like receptor signaling pathway GO:0034121 ISO
    ionotropic glutamate receptor signaling pathway GO:0035235 IMP
    regulation of multicellular organism growth GO:0040014 IMP
    positive regulation of apoptotic process GO:0043065 ISO
    positive regulation of apoptotic process GO:0043065 ISO
    regulation of protein binding GO:0043393 IGI
    regulation of protein binding GO:0043393 IMP
    positive regulation of MAPK cascade GO:0043410 ISO
    positive regulation of neuron apoptotic process GO:0043525 ISO
    innate immune response GO:0045087 ISO
    positive regulation of nitric oxide biosynthetic process GO:0045429 ISO
    negative regulation of neuron differentiation GO:0045665 IDA
    negative regulation of neuron differentiation GO:0045665 IGI
    positive regulation of neuron differentiation GO:0045666 ISO
    positive regulation of G protein-coupled receptor signaling pathway GO:0045745 ISO
    positive regulation of Toll signaling pathway GO:0045752 ISO
    positive regulation of glycolytic process GO:0045821 IEA
    positive regulation of glycolytic process GO:0045821 ISO
    positive regulation of mitotic cell cycle GO:0045931 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IGI
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    positive regulation of JNK cascade GO:0046330 IEA
    positive regulation of JNK cascade GO:0046330 ISO
    astrocyte activation GO:0048143 ISO
    regulation of long-term neuronal synaptic plasticity GO:0048169 IEA
    regulation of long-term neuronal synaptic plasticity GO:0048169 ISO
    collateral sprouting in absence of injury GO:0048669 IGI
    positive regulation of inflammatory response GO:0050729 IEA
    positive regulation of inflammatory response GO:0050729 ISO
    regulation of peptidyl-tyrosine phosphorylation GO:0050730 ISO
    regulation of synapse structure or activity GO:0050803 IMP
    synapse organization GO:0050808 ISO
    defense response to Gram-negative bacterium GO:0050829 ISO
    defense response to Gram-positive bacterium GO:0050830 ISO
    positive regulation of calcium-mediated signaling GO:0050850 IEA
    positive regulation of calcium-mediated signaling GO:0050850 ISO
    neuromuscular process controlling balance GO:0050885 IGI
    cognition GO:0050890 IDA
    positive regulation of membrane protein ectodomain proteolysis GO:0051044 ISO
    synaptic assembly at neuromuscular junction GO:0051124 IGI
    positive regulation of protein metabolic process GO:0051247 ISO
    protein homooligomerization GO:0051260 ISO
    protein tetramerization GO:0051262 ISO
    neuron apoptotic process GO:0051402 IGI
    neuron apoptotic process GO:0051402 ISO
    smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 IGI
    regulation of neurotransmitter uptake GO:0051580 ISO
    low-density lipoprotein particle mediated signaling GO:0055096 ISO
    long-term synaptic potentiation GO:0060291 TAS
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 ISO
    neuron cellular homeostasis GO:0070050 IGI
    protein trimerization GO:0070206 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    response to interleukin-1 GO:0070555 ISO
    cellular response to norepinephrine stimulus GO:0071874 ISO
    positive regulation of monocyte chemotaxis GO:0090026 ISO
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISO
    modulation of excitatory postsynaptic potential GO:0098815 IEA
    modulation of excitatory postsynaptic potential GO:0098815 ISO
    positive regulation of gene expression, epigenetic GO:0141137 ISO
    regulation of spontaneous synaptic transmission GO:0150003 IEA
    regulation of spontaneous synaptic transmission GO:0150003 ISO
    cytosolic mRNA polyadenylation GO:0180011 IDA
    negative regulation of protein localization to nucleus GO:1900181 ISO
    regulation of amyloid-beta clearance GO:1900221 ISO
    negative regulation of long-term synaptic potentiation GO:1900272 IEA
    negative regulation of long-term synaptic potentiation GO:1900272 ISO
    positive regulation of long-term synaptic potentiation GO:1900273 IEA
    positive regulation of long-term synaptic potentiation GO:1900273 ISO
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 IEA
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 ISO
    negative regulation of miRNA transcription GO:1902894 ISO
    regulation of dendritic spine maintenance GO:1902950 ISO
    positive regulation of amyloid precursor protein catabolic process GO:1902993 ISO
    regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway GO:1903381 ISO
    negative regulation of blood circulation GO:1903523 IGI
    negative regulation of blood circulation GO:1903523 ISO
    positive regulation of G protein-coupled receptor internalization GO:1904022 ISO
    positive regulation of endothelin production GO:1904472 IGI
    positive regulation of endothelin production GO:1904472 ISO
    positive regulation of protein import GO:1904591 ISO
    cellular response to amyloid-beta GO:1904646 IEA
    cellular response to amyloid-beta GO:1904646 ISO
    regulation of presynapse assembly GO:1905606 ISO
    negative regulation of presynapse assembly GO:1905607 IMP
    positive regulation of response to endoplasmic reticulum stress GO:1905898 ISO
    regulation of amyloid fibril formation GO:1905906 ISO
    positive regulation of amyloid fibril formation GO:1905908 IEA
    positive regulation of amyloid fibril formation GO:1905908 ISO
    regulation of response to calcium ion GO:1905945 ISO
    amyloid fibril formation GO:1990000 IEA
    amyloid fibril formation GO:1990000 ISO
    neuron projection maintenance GO:1990535 IEA
    neuron projection maintenance GO:1990535 ISO
    positive regulation of T cell migration GO:2000406 IEA
    positive regulation of T cell migration GO:2000406 ISO
    positive regulation of excitatory postsynaptic potential GO:2000463 ISO
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 ISO
Subcellular Localization
    extracellular space GO:0005615 IEA
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISO
    nucleus GO:0005634 ISO
    nuclear envelope lumen GO:0005641 IEA
    nuclear envelope lumen GO:0005641 ISO
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 ISO
    lysosome GO:0005764 ISO
    endosome GO:0005768 ISO
    early endosome GO:0005769 IBA
    early endosome GO:0005769 IDA
    early endosome GO:0005769 ISO
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum GO:0005783 ISS
    smooth endoplasmic reticulum GO:0005790 IEA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 ISO
    Golgi-associated vesicle GO:0005798 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISO
    clathrin-coated pit GO:0005905 IEA
    cell-cell junction GO:0005911 IDA
    synaptic vesicle GO:0008021 IDA
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    membrane GO:0016020 IDA
    membrane GO:0016020 ISO
    membrane GO:0016020 TAS
    COPII-coated ER to Golgi transport vesicle GO:0030134 IDA
    axon GO:0030424 IDA
    axon GO:0030424 IMP
    axon GO:0030424 ISO
    dendrite GO:0030425 ISO
    growth cone GO:0030426 IEA
    growth cone GO:0030426 ISO
    cytoplasmic vesicle GO:0031410 IDA
    neuromuscular junction GO:0031594 IDA
    protein-containing complex GO:0032991 ISO
    very-low-density lipoprotein particle GO:0034361 ISO
    low-density lipoprotein particle GO:0034362 ISO
    intermediate-density lipoprotein particle GO:0034363 ISO
    high-density lipoprotein particle GO:0034364 ISO
    ciliary rootlet GO:0035253 IDA
    neuron projection GO:0043005 IDA
    neuron projection GO:0043005 ISO
    dendritic spine GO:0043197 IEA
    dendritic shaft GO:0043198 IEA
    perikaryon GO:0043204 IEA
    receptor complex GO:0043235 ISO
    cell body GO:0044297 ISO
    main axon GO:0044304 ISO
    membrane raft GO:0045121 IBA
    membrane raft GO:0045121 IEA
    membrane raft GO:0045121 ISO
    apical part of cell GO:0045177 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
    presynaptic active zone GO:0048786 IDA
    presynaptic active zone GO:0048786 IEP
    spindle midzone GO:0051233 IDA
    recycling endosome GO:0055037 IDA
    endosome to plasma membrane transport vesicle GO:0070381 ISO
    astrocyte projection GO:0097449 ISO
    intracellular vesicle GO:0097708 IDA
    presynapse GO:0098793 ISO
    postsynapse GO:0098794 ISO
    neuronal dense core vesicle GO:0098992 ISO
    amyloid-beta complex GO:0106003 ISO
    growth cone lamellipodium GO:1990761 ISO
    lipoprotein particle GO:1990777 ISO
    growth cone filopodium GO:1990812 ISO
 Experiment description of studies that identified App in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
4
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for App
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rlbp1  
Co-fractionation Mus musculus
2 Prnp 19122
Affinity Capture-MS Mus musculus
3 Clu  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
4 Cntn1 12805
Affinity Capture-MS Mus musculus
5 Calr 12317
Affinity Capture-MS Mus musculus
6 Pdia6 71853
Affinity Capture-MS Mus musculus
7 Mat1a 11720
Affinity Capture-MS Mus musculus
8 Stub1 56424
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
9 Hsp90b1 22027
Affinity Capture-MS Mus musculus
10 Thy1 21838
Affinity Capture-MS Mus musculus
11 Ppp1r2  
Affinity Capture-MS Mus musculus
12 Calu  
Affinity Capture-MS Mus musculus
13 Egf  
Affinity Capture-Western Mus musculus
14 Kif1a  
Affinity Capture-Western Mus musculus
15 Tmem173  
Proximity Label-MS Mus musculus
16 Oat  
Affinity Capture-MS Mus musculus
17 Kdr  
Affinity Capture-Western Mus musculus
18 Aplp1 11803
Affinity Capture-MS Mus musculus
19 Epb4.1l3 13823
Affinity Capture-MS Mus musculus
20 Ranbp9  
Affinity Capture-Western Mus musculus
21 Ngfr 18053
Affinity Capture-Western Mus musculus
22 Cst3  
Affinity Capture-MS Mus musculus
23 Vps33b  
Co-fractionation Mus musculus
24 Cpe 12876
Affinity Capture-MS Mus musculus
25 Sorl1  
Affinity Capture-Western Mus musculus
26 Snca  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
27 Ppib 19035
Affinity Capture-MS Mus musculus
28 Hspa5 14828
Affinity Capture-MS Mus musculus
29 Spon1 233744
Affinity Capture-MS Mus musculus
30 Gga1  
FRET Mus musculus
31 Canx 12330
Affinity Capture-MS Mus musculus
32 Rcn2  
Affinity Capture-MS Mus musculus
33 Tmod2  
Co-fractionation Mus musculus
34 Aplp2 11804
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which App is involved
PathwayEvidenceSource
Advanced glycosylation endproduct receptor signaling IEA Reactome
Class A/1 (Rhodopsin-like receptors) IEA Reactome
Cytokine Signaling in Immune system IEA Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta IEA Reactome
ECM proteoglycans IEA Reactome
Extracellular matrix organization IEA Reactome
Formyl peptide receptors bind formyl peptides and many other ligands IEA Reactome
G alpha (i) signalling events IEA Reactome
G alpha (q) signalling events IEA Reactome
GPCR downstream signalling IEA Reactome
GPCR ligand binding IEA Reactome
Hemostasis IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane IEA Reactome
Interleukin-1 family signaling IEA Reactome
Interleukin-1 signaling IEA Reactome
Lysosome Vesicle Biogenesis IEA Reactome
Membrane Trafficking IEA Reactome
Metabolism of proteins IEA Reactome
Mitochondrial protein degradation IEA Reactome
MyD88 cascade initiated on plasma membrane IEA Reactome
MyD88 dependent cascade initiated on endosome IEA Reactome
MyD88-independent TLR4 cascade IEA Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane IEA Reactome
Peptide ligand-binding receptors IEA Reactome
Platelet activation, signaling and aggregation IEA Reactome
Platelet degranulation IEA Reactome
Post-translational protein modification IEA Reactome
Post-translational protein phosphorylation IEA Reactome
Protein localization IEA Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) IEA Reactome
Response to elevated platelet cytosolic Ca2+ IEA Reactome
Signal Transduction IEA Reactome
Signaling by GPCR IEA Reactome
Signaling by Interleukins IEA Reactome
TAK1-dependent IKK and NF-kappa-B activation IEA Reactome
Toll Like Receptor 10 (TLR10) Cascade IEA Reactome
Toll Like Receptor 2 (TLR2) Cascade IEA Reactome
Toll Like Receptor 3 (TLR3) Cascade IEA Reactome
Toll Like Receptor 4 (TLR4) Cascade IEA Reactome
Toll Like Receptor 5 (TLR5) Cascade IEA Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade IEA Reactome
Toll Like Receptor 9 (TLR9) Cascade IEA Reactome
Toll Like Receptor TLR1:TLR2 Cascade IEA Reactome
Toll Like Receptor TLR6:TLR2 Cascade IEA Reactome
Toll-like Receptor Cascades IEA Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IEA Reactome
TRAF6 mediated NF-kB activation IEA Reactome
trans-Golgi Network Vesicle Budding IEA Reactome
TRIF (TICAM1)-mediated TLR4 signaling IEA Reactome
Vesicle-mediated transport IEA Reactome





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