Gene description for Ppib
Gene name peptidylprolyl isomerase B
Gene symbol Ppib
Other names/aliases AA408962
AA553318
AI844835
Cphn-2
Cphn2
CyP-20b
Species Mus musculus
 Database cross references - Ppib
ExoCarta ExoCarta_19035
Vesiclepedia VP_19035
Entrez Gene 19035
UniProt P24369  
 Ppib identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Pancreatic cells 19351151    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ppib
Molecular Function
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 ISO
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 ISS
    protein binding GO:0005515 IPI
    protein binding GO:0005515 ISS
    collagen binding GO:0005518 ISS
    cyclosporin A binding GO:0016018 IBA
    cyclosporin A binding GO:0016018 ISO
    RNA polymerase binding GO:0070063 IEA
    RNA polymerase binding GO:0070063 ISO
    RNA polymerase II CTD heptapeptide repeat P3 isomerase activity GO:0140839 IEA
    RNA polymerase II CTD heptapeptide repeat P6 isomerase activity GO:0140840 IEA
Biological Process
    protein peptidyl-prolyl isomerization GO:0000413 ISO
    protein peptidyl-prolyl isomerization GO:0000413 ISS
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    protein folding GO:0006457 IBA
    neutrophil chemotaxis GO:0030593 IEA
    neutrophil chemotaxis GO:0030593 ISO
    positive regulation of multicellular organism growth GO:0040018 IEA
    positive regulation of multicellular organism growth GO:0040018 ISO
    positive regulation by host of viral process GO:0044794 ISO
    positive regulation by host of viral genome replication GO:0044829 IEA
    positive regulation by host of viral genome replication GO:0044829 ISO
    protein stabilization GO:0050821 IEA
    protein stabilization GO:0050821 ISO
    bone development GO:0060348 IEA
    bone development GO:0060348 ISO
    chaperone-mediated protein folding GO:0061077 ISO
    chaperone-mediated protein folding GO:0061077 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IBA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum lumen GO:0005788 IEA
    smooth endoplasmic reticulum GO:0005790 IEA
    smooth endoplasmic reticulum GO:0005790 ISO
    protein-containing complex GO:0032991 ISS
    endoplasmic reticulum chaperone complex GO:0034663 IDA
    melanosome GO:0042470 IEA
    intracellular membrane-bounded organelle GO:0043231 IBA
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Ppib in sEVs
1
Experiment ID 907
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 188
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ppib
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Mettl21e  
Affinity Capture-MS Mus musculus
3 Ubqln4  
Co-fractionation Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
5 App 11820
Affinity Capture-MS Mus musculus
6 Sdf2l1  
Co-fractionation Mus musculus
7 Eed  
Affinity Capture-MS Mus musculus
8 Hsp90b1 22027
Co-fractionation Mus musculus
9 Dlg4  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
10 Mapt  
Affinity Capture-MS Mus musculus
11 Zyx  
Co-fractionation Mus musculus
12 Sgta 52551
Co-fractionation Mus musculus
13 Os9  
Co-fractionation Mus musculus
14 Lipc  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Ppib is involved
No pathways found





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