Gene description for NUDT16
Gene name nudix (nucleoside diphosphate linked moiety X)-type motif 16
Gene symbol NUDT16
Other names/aliases -
Species Homo sapiens
 Database cross references - NUDT16
ExoCarta ExoCarta_131870
Vesiclepedia VP_131870
Entrez Gene 131870
HGNC 26442
UniProt Q96DE0  
 NUDT16 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NUDT16
Molecular Function
    nucleotide binding GO:0000166 IEA
    magnesium ion binding GO:0000287 IDA
    mRNA binding GO:0003729 IDA
    metalloexopeptidase activity GO:0008235 IDA
    manganese ion binding GO:0030145 IDA
    snoRNA binding GO:0030515 IBA
    snoRNA binding GO:0030515 IDA
    chloride ion binding GO:0031404 IDA
    dITP diphosphatase activity GO:0035870 ISS
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    cobalt ion binding GO:0050897 IDA
    dIDP phosphatase activity GO:0097383 IEA
    RNA NAD-cap (NMN-forming) hydrolase activity GO:0110153 IEA
    5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity GO:0140933 IDA
    IDP phosphatase activity GO:1990003 IDA
    phosphodiesterase decapping endonuclease activity GO:1990174 IBA
    phosphodiesterase decapping endonuclease activity GO:1990174 IDA
Biological Process
    mRNA catabolic process GO:0006402 IBA
    mRNA catabolic process GO:0006402 IDA
    sno(s)RNA catabolic process GO:0016077 IBA
    sno(s)RNA catabolic process GO:0016077 IDA
    dITP catabolic process GO:0035863 ISS
    positive regulation of cell cycle process GO:0090068 IMP
    NAD-cap decapping GO:0110155 IDA
    negative regulation of rRNA processing GO:2000233 ISS
Subcellular Localization
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified NUDT16 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NUDT16
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FAN1  
Affinity Capture-MS Homo sapiens
2 UBR2 23304
Affinity Capture-MS Homo sapiens
3 CDC14B 8555
Affinity Capture-MS Homo sapiens
4 PRC1 9055
Two-hybrid Homo sapiens
5 KCTD12 115207
Affinity Capture-MS Homo sapiens
6 CRAT 1384
Affinity Capture-MS Homo sapiens
7 ATP12A 479
Affinity Capture-MS Homo sapiens
8 MTMR10 54893
Affinity Capture-MS Homo sapiens
9 MTMR2 8898
Affinity Capture-MS Homo sapiens
10 IL1R2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ACSF2 80221
Affinity Capture-MS Homo sapiens
12 NUDT16L1 84309
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PTP4A1 7803
Affinity Capture-MS Homo sapiens
14 MTIF2 4528
Affinity Capture-MS Homo sapiens
15 BCKDK 10295
Affinity Capture-MS Homo sapiens
16 D2HGDH 728294
Affinity Capture-MS Homo sapiens
17 PTPN6 5777
Affinity Capture-MS Homo sapiens
18 COL20A1  
Affinity Capture-MS Homo sapiens
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