Gene description for NUDT16L1
Gene name nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1
Gene symbol NUDT16L1
Other names/aliases SDOS
Species Homo sapiens
 Database cross references - NUDT16L1
ExoCarta ExoCarta_84309
Vesiclepedia VP_84309
Entrez Gene 84309
HGNC 28154
UniProt Q9BRJ7  
 NUDT16L1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for NUDT16L1
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    snoRNA binding GO:0030515 IBA
    snoRNA binding GO:0030515 IDA
    protein homodimerization activity GO:0042803 IDA
    5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity GO:0140933 IDA
    5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity GO:0140933 ISS
    phosphodiesterase decapping endonuclease activity GO:1990174 IBA
Biological Process
    mRNA catabolic process GO:0006402 IBA
    sno(s)RNA catabolic process GO:0016077 IBA
    negative regulation of double-strand break repair via nonhomologous end joining GO:2001033 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified NUDT16L1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NUDT16L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
2 CLPP 8192
Proximity Label-MS Homo sapiens
3 MECP2 4204
Affinity Capture-MS Homo sapiens
4 CUL1 8454
Affinity Capture-MS Homo sapiens
5 CABP2  
Two-hybrid Homo sapiens
6 MYCN  
Affinity Capture-MS Homo sapiens
7 HNRNPH2 3188
Affinity Capture-MS Homo sapiens
8 TRAF2 7186
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 SLC25A12 8604
Proximity Label-MS Homo sapiens
10 TRIM31  
Affinity Capture-MS Homo sapiens
11 TP53BP1 7158
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 NEK6 10783
Two-hybrid Homo sapiens
13 RIN3  
Affinity Capture-MS Homo sapiens
14 IKZF3  
Two-hybrid Homo sapiens
15 E2F4  
Affinity Capture-MS Homo sapiens
16 AURKA 6790
Affinity Capture-MS Homo sapiens
17 CRYAB 1410
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 INCA1  
Two-hybrid Homo sapiens
19 UBA1 7317
Affinity Capture-MS Homo sapiens
20 NEUROG3  
Affinity Capture-MS Homo sapiens
21 CUL3 8452
Affinity Capture-MS Homo sapiens
22 NTNG1  
Affinity Capture-MS Homo sapiens
23 CAND1 55832
Affinity Capture-MS Homo sapiens
24 PNMA1 9240
Two-hybrid Homo sapiens
25 TRIM68 55128
Two-hybrid Homo sapiens
26 TCEAL1  
Affinity Capture-MS Homo sapiens
27 SOX2  
Affinity Capture-MS Homo sapiens
28 APP 351
Reconstituted Complex Homo sapiens
29 CUL4B 8450
Affinity Capture-MS Homo sapiens
30 CAPZB 832
Affinity Capture-MS Homo sapiens
31 HECW2  
Affinity Capture-MS Homo sapiens
32 WDYHV1  
Two-hybrid Homo sapiens
33 Nedd4 25489
Reconstituted Complex Rattus norvegicus
34 MCM2 4171
Affinity Capture-MS Homo sapiens
35 TRIM11  
Affinity Capture-MS Homo sapiens
36 NUDT16 131870
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 Trp53bp1  
Affinity Capture-MS Mus musculus
38 VEGFB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 HNRNPF 3185
Two-hybrid Homo sapiens
40 COPS5 10987
Affinity Capture-MS Homo sapiens
41 RECK 8434
Two-hybrid Homo sapiens
42 TIMM23 100287932
Affinity Capture-MS Homo sapiens
43 CUL7 9820
Affinity Capture-MS Homo sapiens
44 RNF2  
Affinity Capture-MS Homo sapiens
45 BMI1  
Affinity Capture-MS Homo sapiens
46 METTL17  
Two-hybrid Homo sapiens
47 FBXO38 81545
Proximity Label-MS Homo sapiens
48 RPA3 6119
Proximity Label-MS Homo sapiens
49 CEBPA  
Protein-peptide Homo sapiens
50 NEDD4L 23327
Reconstituted Complex Homo sapiens
51 NEDD8 4738
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NUDT16L1 is involved
No pathways found





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