Gene description for Reln
Gene name reelin
Gene symbol Reln
Other names/aliases reeler
rl
Species Mus musculus
 Database cross references - Reln
ExoCarta ExoCarta_19699
Vesiclepedia VP_19699
Entrez Gene 19699
UniProt Q60841  
 Reln identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Reln
Molecular Function
    extracellular matrix structural constituent GO:0005201 RCA
    protein binding GO:0005515 IPI
    serine-type peptidase activity GO:0008236 IDA
    metal ion binding GO:0046872 IEA
    receptor ligand activity GO:0048018 IDA
    lipoprotein particle receptor binding GO:0070325 IBA
    lipoprotein particle receptor binding GO:0070325 IPI
    very-low-density lipoprotein particle receptor binding GO:0070326 IPI
Biological Process
    cell morphogenesis GO:0000902 IMP
    neuron migration GO:0001764 IBA
    neuron migration GO:0001764 IGI
    neuron migration GO:0001764 IMP
    neuron migration GO:0001764 ISO
    proteolysis GO:0006508 IEA
    cell adhesion GO:0007155 IEA
    axon guidance GO:0007411 IMP
    central nervous system development GO:0007417 IBA
    central nervous system development GO:0007417 IMP
    brain development GO:0007420 IMP
    learning GO:0007612 IMP
    long-term memory GO:0007616 IDA
    long-term memory GO:0007616 IMP
    locomotory behavior GO:0007626 IMP
    locomotory behavior GO:0007626 ISO
    associative learning GO:0008306 IDA
    associative learning GO:0008306 IMP
    glial cell differentiation GO:0010001 IMP
    regulation of gene expression GO:0010468 IMP
    positive regulation of neuron projection development GO:0010976 IMP
    dendrite development GO:0016358 IGI
    dendrite development GO:0016358 IMP
    cell migration GO:0016477 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    spinal cord patterning GO:0021511 IMP
    ventral spinal cord development GO:0021517 IEP
    dentate gyrus development GO:0021542 ISO
    hippocampus development GO:0021766 IDA
    cerebral cortex tangential migration GO:0021800 IMP
    layer formation in cerebral cortex GO:0021819 IDA
    layer formation in cerebral cortex GO:0021819 IMP
    cerebral cortex development GO:0021987 IMP
    forebrain development GO:0030900 IMP
    positive regulation of TOR signaling GO:0032008 IDA
    positive regulation of CREB transcription factor activity GO:0032793 IMP
    protein localization to synapse GO:0035418 IMP
    reelin-mediated signaling pathway GO:0038026 IDA
    reelin-mediated signaling pathway GO:0038026 NAS
    thyroid hormone metabolic process GO:0042403 IMP
    regulation of neuron differentiation GO:0045664 NAS
    positive regulation of protein kinase activity GO:0045860 IDA
    positive regulation of protein kinase activity GO:0045860 IGI
    response to pain GO:0048265 IMP
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    regulation of behavior GO:0050795 IMP
    modulation of chemical synaptic transmission GO:0050804 IMP
    positive regulation of small GTPase mediated signal transduction GO:0051057 IDA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA
    positive regulation of synaptic transmission, glutamatergic GO:0051968 IDA
    positive regulation of synaptic transmission, glutamatergic GO:0051968 IMP
    regulation of synaptic activity GO:0060025 NAS
    long-term synaptic potentiation GO:0060291 IMP
    positive regulation of dendritic spine morphogenesis GO:0061003 IDA
    positive regulation of dendritic spine morphogenesis GO:0061003 IMP
    positive regulation of protein tyrosine kinase activity GO:0061098 IMP
    regulation of synapse maturation GO:0090128 IDA
    regulation of synapse maturation GO:0090128 IMP
    positive regulation of synapse maturation GO:0090129 IDA
    positive regulation of synapse maturation GO:0090129 IMP
    postsynaptic density assembly GO:0097107 IMP
    NMDA glutamate receptor clustering GO:0097114 IMP
    postsynaptic density protein 95 clustering GO:0097119 IMP
    receptor localization to synapse GO:0097120 IMP
    motor neuron migration GO:0097475 IMP
    lateral motor column neuron migration GO:0097477 IMP
    positive regulation of long-term synaptic potentiation GO:1900273 IDA
    positive regulation of lateral motor column neuron migration GO:1902078 IMP
    interneuron migration GO:1904936 IMP
    regulation of NMDA receptor activity GO:2000310 IMP
    positive regulation of excitatory postsynaptic potential GO:2000463 IDA
    positive regulation of excitatory postsynaptic potential GO:2000463 IMP
    positive regulation of AMPA receptor activity GO:2000969 IMP
    regulation of neuron migration GO:2001222 NAS
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IEA
    axon GO:0030424 ISO
    dendrite GO:0030425 IDA
    dendrite GO:0030425 ISO
    extracellular matrix GO:0031012 IDA
    extracellular matrix GO:0031012 TAS
    neuron projection GO:0043005 IBA
    neuronal cell body GO:0043025 ISO
    perikaryon GO:0043204 ISO
    collagen-containing extracellular matrix GO:0062023 HDA
    reelin complex GO:0110157 ISO
 Experiment description of studies that identified Reln in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Reln
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Idh2 269951
Cross-Linking-MS (XL-MS) Mus musculus
2 Pcdha10  
Reconstituted Complex Mus musculus
3 Pafah1b1 18472
Phenotypic Enhancement Mus musculus
4 Efnb2  
Co-fractionation Mus musculus
5 Lrp8  
Co-fractionation Mus musculus
6 Pcdha4  
Affinity Capture-Western Mus musculus
7 Vldlr  
Co-fractionation Mus musculus
8 Cnr1  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
9 Cnr2  
Reconstituted Complex Mus musculus
View the network image/svg+xml
 Pathways in which Reln is involved
PathwayEvidenceSource
Axon guidance IEA Reactome
Developmental Biology IEA Reactome
Nervous system development IEA Reactome
Reelin signalling pathway IEA Reactome





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