Gene description for Sod2
Gene name	superoxide dismutase 2, mitochondrial
Gene symbol	Sod2
Other names/aliases	MnSOD Sod-2
Species	Mus musculus
Database cross references - Sod2
ExoCarta	ExoCarta_20656
Vesiclepedia	VP_20656
Entrez Gene	20656
UniProt	P09671
Sod2 identified in sEVs derived from the following tissue/cell type
Pancreatic cells	19351151

Gene ontology annotations for Sod2

Molecular Function     DNA binding GO:0003677 IEA     DNA binding GO:0003677 ISO     superoxide dismutase activity GO:0004784 IBA     superoxide dismutase activity GO:0004784 IDA     superoxide dismutase activity GO:0004784 IMP     superoxide dismutase activity GO:0004784 ISO     superoxide dismutase activity GO:0004784 ISS     protein binding GO:0005515 IPI     oxidoreductase activity GO:0016491 IMP     oxygen binding GO:0019825 IEA     oxygen binding GO:0019825 ISO     enzyme binding GO:0019899 IEA     enzyme binding GO:0019899 ISO     manganese ion binding GO:0030145 IBA     manganese ion binding GO:0030145 ISO     manganese ion binding GO:0030145 ISS     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO Biological Process     response to reactive oxygen species GO:0000302 IMP     response to superoxide GO:0000303 IMP     response to superoxide GO:0000303 ISO     response to hypoxia GO:0001666 IEA     release of cytochrome c from mitochondria GO:0001836 IMP     liver development GO:0001889 IMP     detection of oxygen GO:0003032 IMP     acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0003069 IMP     regulation of transcription by RNA polymerase II GO:0006357 IDA     regulation of transcription by RNA polymerase II GO:0006357 ISO     regulation of transcription by RNA polymerase II GO:0006357 ISS     glutathione metabolic process GO:0006749 IMP     superoxide metabolic process GO:0006801 IMP     superoxide metabolic process GO:0006801 ISO     superoxide metabolic process GO:0006801 ISS     response to oxidative stress GO:0006979 IGI     response to oxidative stress GO:0006979 IMP     mitochondrion organization GO:0007005 IMP     heart development GO:0007507 IMP     sensory perception of sound GO:0007605 IMP     locomotory behavior GO:0007626 IMP     regulation of blood pressure GO:0008217 IMP     negative regulation of cell population proliferation GO:0008285 ISO     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IMP     intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 IMP     apoptotic mitochondrial changes GO:0008637 IMP     response to xenobiotic stimulus GO:0009410 IEA     response to xenobiotic stimulus GO:0009410 ISO     post-embryonic development GO:0009791 IMP     response to manganese ion GO:0010042 IEA     response to zinc ion GO:0010043 IEA     response to selenium ion GO:0010269 IEA     response to gamma radiation GO:0010332 IGI     positive regulation of hydrogen peroxide biosynthetic process GO:0010729 IEA     positive regulation of hydrogen peroxide biosynthetic process GO:0010729 ISO     response to activity GO:0014823 IMP     removal of superoxide radicals GO:0019430 IMP     removal of superoxide radicals GO:0019430 ISO     respiratory electron transport chain GO:0022904 IMP     hemopoiesis GO:0030097 IMP     positive regulation of cell migration GO:0030335 IEA     positive regulation of cell migration GO:0030335 ISO     response to nutrient levels GO:0031667 ISO     intracellular oxygen homeostasis GO:0032364 IEA     intracellular oxygen homeostasis GO:0032364 ISO     response to lipopolysaccharide GO:0032496 IEA     response to L-ascorbic acid GO:0033591 IEA     response to silicon dioxide GO:0034021 IEA     cellular response to oxidative stress GO:0034599 ISS     response to isolation stress GO:0035900 IEA     response to immobilization stress GO:0035902 IEA     vasodilation GO:0042311 IMP     response to hydrogen peroxide GO:0042542 IMP     superoxide anion generation GO:0042554 IMP     hydrogen peroxide metabolic process GO:0042743 ISO     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of neuron apoptotic process GO:0043524 IEA     negative regulation of neuron apoptotic process GO:0043524 ISO     positive regulation of nitric oxide biosynthetic process GO:0045429 IMP     negative regulation of fat cell differentiation GO:0045599 IMP     response to cadmium ion GO:0046686 IEA     negative regulation of fibroblast proliferation GO:0048147 IDA     neuron development GO:0048666 IMP     response to axon injury GO:0048678 IMP     erythrophore differentiation GO:0048773 IMP     hydrogen peroxide biosynthetic process GO:0050665 IEA     hydrogen peroxide biosynthetic process GO:0050665 ISO     regulation of catalytic activity GO:0050790 IMP     protein homotetramerization GO:0051289 IEA     protein homotetramerization GO:0051289 ISO     response to electrical stimulus GO:0051602 IEA     regulation of mitochondrial membrane potential GO:0051881 IMP     response to hyperoxia GO:0055093 IMP     multicellular organismal-level iron ion homeostasis GO:0060586 IMP     response to magnetism GO:0071000 IEA     cellular response to ethanol GO:0071361 IEA     negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 IEA     negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 ISO     negative regulation of membrane hyperpolarization GO:1902631 IEA     negative regulation of membrane hyperpolarization GO:1902631 ISO     negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IEA     negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 ISO     positive regulation of vascular associated smooth muscle cell apoptotic process GO:1905461 IEA     positive regulation of vascular associated smooth muscle cell apoptotic process GO:1905461 ISO     positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching GO:1905932 IEA     positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching GO:1905932 ISO Subcellular Localization     mitochondrion GO:0005739 HDA     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 IDA     mitochondrion GO:0005739 ISO     mitochondrial inner membrane GO:0005743 HDA     mitochondrial matrix GO:0005759 ISO     mitochondrial nucleoid GO:0042645 IEA     mitochondrial nucleoid GO:0042645 ISO     myelin sheath GO:0043209 HDA