Gene description for Trove2
Gene name TROVE domain family, member 2
Gene symbol Trove2
Other names/aliases 1810007I17Rik
A530054J02Rik
AI646302
SS-A/Ro
Ssa
Ssa2
Species Mus musculus
 Database cross references - Trove2
ExoCarta ExoCarta_20822
Vesiclepedia VP_20822
Entrez Gene 20822
UniProt O08848  
 Trove2 identified in sEVs derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Trove2
Molecular Function
    RNA binding GO:0003723 IBA
    RNA binding GO:0003723 IDA
    RNA binding GO:0003723 ISO
    U2 snRNA binding GO:0030620 IDA
    misfolded RNA binding GO:0034336 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    immune system development GO:0002520 IMP
    smoothened signaling pathway GO:0007224 IMP
    response to UV GO:0009411 IDA
    response to UV GO:0009411 IMP
    regulation of gene expression GO:0010468 ISO
    regulation of gene expression GO:0010468 ISS
    cellular response to interferon-alpha GO:0035457 ISO
    cellular response to interferon-alpha GO:0035457 ISS
    cilium assembly GO:0060271 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    nuclear body GO:0016604 IEA
    nuclear body GO:0016604 ISO
    ribonucleoprotein complex GO:1990904 IBA
    ribonucleoprotein complex GO:1990904 IDA
    ribonucleoprotein complex GO:1990904 ISO
    ribonucleoprotein complex GO:1990904 ISS
 Experiment description of studies that identified Trove2 in sEVs
1
Experiment ID 214
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Trove2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rps8 20116
Co-fractionation Mus musculus
2 Rps3 27050
Co-fractionation Mus musculus
3 Rpl26 19941
Co-fractionation Mus musculus
4 Rplp0 11837
Co-fractionation Mus musculus
5 Ybx1 22608
Co-fractionation Mus musculus
6 Xpo7  
Co-fractionation Mus musculus
7 Ranbp3  
Co-fractionation Mus musculus
8 Rpl13a 22121
Co-fractionation Mus musculus
9 Sec23a  
Co-fractionation Mus musculus
10 Ago2 239528
Co-fractionation Mus musculus
11 Actn4 60595
Co-fractionation Mus musculus
12 Unk  
Affinity Capture-RNA Mus musculus
13 Rps4x 20102
Co-fractionation Mus musculus
14 Ssb 20823
Co-fractionation Mus musculus
15 Syncrip 56403
Co-fractionation Mus musculus
16 Fancd2  
Affinity Capture-MS Mus musculus
17 Rps3a1 20091
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Trove2 is involved
No pathways found





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