Gene description for Coq6
Gene name coenzyme Q6 homolog (yeast)
Gene symbol Coq6
Other names/aliases 5930427M12Rik
AW742344
Species Mus musculus
 Database cross references - Coq6
ExoCarta ExoCarta_217707
Vesiclepedia VP_217707
Entrez Gene 217707
UniProt Q8R1S0  
 Coq6 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Coq6
Molecular Function
    oxidoreductase activity GO:0016491 IBA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 IEA
    FAD binding GO:0071949 IEA
    4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity GO:0106364 IEA
Biological Process
    ubiquinone biosynthetic process GO:0006744 IBA
    ubiquinone biosynthetic process GO:0006744 IEA
    ubiquinone biosynthetic process GO:0006744 NAS
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 ISO
    Golgi apparatus GO:0005794 IEA
    extrinsic component of mitochondrial inner membrane GO:0031314 IEA
    cell projection GO:0042995 IEA
    ubiquinone biosynthesis complex GO:0110142 IEA
    ubiquinone biosynthesis complex GO:0110142 ISO
 Experiment description of studies that identified Coq6 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Coq6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atxn1  
Affinity Capture-MS Mus musculus
2 Ddx46  
Cross-Linking-MS (XL-MS) Mus musculus
3 Coq3  
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
4 Mdh2 17448
Cross-Linking-MS (XL-MS) Mus musculus
5 Coq6 217707
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
View the network image/svg+xml
 Pathways in which Coq6 is involved
PathwayEvidenceSource
Metabolism IEA Reactome
Metabolism of cofactors IEA Reactome
Metabolism of vitamins and cofactors IEA Reactome
Ubiquinol biosynthesis IEA Reactome





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