Gene description for FANCG
Gene name Fanconi anemia, complementation group G
Gene symbol FANCG
Other names/aliases FAG
XRCC9
Species Homo sapiens
 Database cross references - FANCG
ExoCarta ExoCarta_2189
Vesiclepedia VP_2189
Entrez Gene 2189
HGNC 3588
MIM 602956
UniProt O15287  
 FANCG identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FANCG
Molecular Function
    damaged DNA binding GO:0003684 TAS
    protein binding GO:0005515 IPI
Biological Process
    ovarian follicle development GO:0001541 IEA
    DNA repair GO:0006281 TAS
    DNA damage response GO:0006974 IBA
    mitochondrion organization GO:0007005 IMP
    spermatid development GO:0007286 IEA
    response to radiation GO:0009314 IEA
    interstrand cross-link repair GO:0036297 NAS
Subcellular Localization
    chromatin GO:0000785 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    Fanconi anaemia nuclear complex GO:0043240 IBA
    Fanconi anaemia nuclear complex GO:0043240 IDA
    Fanconi anaemia nuclear complex GO:0043240 NAS
 Experiment description of studies that identified FANCG in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FANCG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FAN1  
Affinity Capture-MS Homo sapiens
2 BLM 641
Affinity Capture-Western Homo sapiens
3 RPA1 6117
Affinity Capture-Western Homo sapiens
4 TGM1 7051
Affinity Capture-MS Homo sapiens
5 CDSN 1041
Affinity Capture-MS Homo sapiens
6 KIF15 56992
Affinity Capture-MS Homo sapiens
7 FTSJ3 117246
Two-hybrid Homo sapiens
8 SPTAN1 6709
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Two-hybrid Homo sapiens
9 USHBP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
10 GYPB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SERPINA12  
Affinity Capture-MS Homo sapiens
12 FANCD2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
13 RTN2 6253
Two-hybrid Homo sapiens
14 GPR17 2840
Affinity Capture-MS Homo sapiens
15 UIMC1  
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
16 FANCC 2176
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
17 HAL 3034
Affinity Capture-MS Homo sapiens
18 CSTF2T  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 XPO1 7514
Affinity Capture-MS Homo sapiens
20 RBPJ 3516
Affinity Capture-Western Homo sapiens
21 DSC3 1825
Affinity Capture-MS Homo sapiens
22 TOP3A  
Affinity Capture-Western Homo sapiens
23 CCDC132 55610
Affinity Capture-MS Homo sapiens
24 LOXL3 84695
Affinity Capture-MS Homo sapiens
25 SERPINB3 6317
Affinity Capture-MS Homo sapiens
26 CTSV 1515
Affinity Capture-MS Homo sapiens
27 TPRX1  
Two-hybrid Homo sapiens
28 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
29 NLGN3  
Two-hybrid Homo sapiens
30 FANCL 55120
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
31 STRA13  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
32 POLN 353497
Affinity Capture-Western Homo sapiens
33 C1orf86  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
34 SPTA1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 FPR1  
Affinity Capture-MS Homo sapiens
36 FANCB  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ERCC4  
Two-hybrid Homo sapiens
39 DPEP1 1800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 VHL  
Negative Genetic Homo sapiens
41 SAMD3  
Two-hybrid Homo sapiens
42 FAM175A  
Affinity Capture-Western Homo sapiens
43 ERCC1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
44 GABPB1  
Two-hybrid Homo sapiens
45 NPTN 27020
Affinity Capture-MS Homo sapiens
46 CDK1 983
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
47 C19orf40  
Affinity Capture-Western Homo sapiens
48 FANCE  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
49 Kat8  
Affinity Capture-MS Mus musculus
50 FANCM 57697
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
51 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 FANCA  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
53 BRCA2 675
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
54 APITD1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
55 TGM3 7053
Affinity Capture-MS Homo sapiens
56 FANCG 2189
Co-purification Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-purification Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
57 PRDX3 10935
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
58 CTBP1 1487
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
59 PAPSS1 9061
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 FANCF  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
61 PINK1  
Affinity Capture-MS Homo sapiens
62 CYP2E1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
63 GPR182  
Affinity Capture-MS Homo sapiens
64 HES1 3280
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
65 C17orf70  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
66 NCCRP1 342897
Affinity Capture-MS Homo sapiens
67 BRCC3 79184
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
68 UBE2T  
Affinity Capture-MS Homo sapiens
69 AR 367
Affinity Capture-MS Homo sapiens
70 XRCC3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
71 Kif1b  
Affinity Capture-MS Mus musculus
72 TCEANC  
Two-hybrid Homo sapiens
73 SERPINB7 8710
Affinity Capture-MS Homo sapiens
74 P2RY8  
Affinity Capture-MS Homo sapiens
75 CAPN1 823
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
76 KRT19 3880
Two-hybrid Homo sapiens
77 PSMB1 5689
Two-hybrid Homo sapiens
78 NOTCH1 4851
Affinity Capture-Western Homo sapiens
79 AZGP1 563
Affinity Capture-MS Homo sapiens
80 GSDMA 284110
Affinity Capture-MS Homo sapiens
81 KPRP 448834
Affinity Capture-MS Homo sapiens
82 ZBED1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
83 ZHX1-C8orf76  
Affinity Capture-MS Homo sapiens
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