Gene description for Vdac2
Gene name voltage-dependent anion channel 2
Gene symbol Vdac2
Other names/aliases Vdac6
mVDAC2
mVDAC6
Species Mus musculus
 Database cross references - Vdac2
ExoCarta ExoCarta_22334
Vesiclepedia VP_22334
Entrez Gene 22334
UniProt Q60930  
 Vdac2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Pancreatic cells 19351151    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Vdac2
Molecular Function
    voltage-gated monoatomic ion channel activity GO:0005244 IDA
    voltage-gated monoatomic ion channel activity GO:0005244 ISS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    oxysterol binding GO:0008142 IMP
    voltage-gated monoatomic anion channel activity GO:0008308 IBA
    voltage-gated monoatomic anion channel activity GO:0008308 IEA
    voltage-gated monoatomic anion channel activity GO:0008308 ISO
    porin activity GO:0015288 IEA
    cholesterol binding GO:0015485 ISO
    cholesterol binding GO:0015485 ISS
    phospholipid scramblase activity GO:0017128 IEA
    phosphatidylcholine binding GO:0031210 ISO
    phosphatidylcholine binding GO:0031210 ISS
    ceramide binding GO:0097001 ISO
    ceramide binding GO:0097001 ISS
Biological Process
    monoatomic anion transport GO:0006820 ISO
    monoatomic anion transport GO:0006820 ISS
    binding of sperm to zona pellucida GO:0007339 IEA
    binding of sperm to zona pellucida GO:0007339 ISO
    plasma membrane phospholipid scrambling GO:0017121 IEA
    negative regulation of protein polymerization GO:0032272 IMP
    mitochondrial outer membrane permeabilization GO:0097345 ISO
    mitochondrial outer membrane permeabilization GO:0097345 ISS
    monoatomic anion transmembrane transport GO:0098656 IEA
    mitochondrial transmembrane transport GO:1990542 IEA
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IMP
Subcellular Localization
    acrosomal vesicle GO:0001669 IEA
    acrosomal vesicle GO:0001669 ISO
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IMP
    mitochondrion GO:0005739 ISO
    mitochondrial outer membrane GO:0005741 IBA
    mitochondrial outer membrane GO:0005741 ISO
    mitochondrial outer membrane GO:0005741 ISS
    mitochondrial inner membrane GO:0005743 HDA
    synaptic vesicle GO:0008021 ISO
    membrane GO:0016020 ISO
    mitochondrial membrane GO:0031966 ISO
    mitochondrial nucleoid GO:0042645 IEA
    mitochondrial nucleoid GO:0042645 ISO
    myelin sheath GO:0043209 HDA
    membrane raft GO:0045121 ISO
    pore complex GO:0046930 IEA
    sperm midpiece GO:0097225 IDA
 Experiment description of studies that identified Vdac2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 188
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|UCHL1|HSP90
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Vdac2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNCA 6622
Affinity Capture-MS Homo sapiens
2 Vdac2 22334
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
3 Rragc  
Co-fractionation Mus musculus
4 Gyk  
Cross-Linking-MS (XL-MS) Mus musculus
5 Kdm2a  
Co-fractionation Mus musculus
6 Rraga  
Co-fractionation Mus musculus
7 Atxn1  
Proximity Label-MS Mus musculus
Affinity Capture-MS Mus musculus
8 Kcna3  
Affinity Capture-MS Mus musculus
9 Kctd13  
Affinity Capture-MS Mus musculus
10 Cox6c  
Cross-Linking-MS (XL-MS) Mus musculus
11 Htt  
Affinity Capture-MS Mus musculus
12 Lamtor2  
Co-fractionation Mus musculus
13 Hk1 15275
Co-fractionation Mus musculus
14 Lamtor3  
Co-fractionation Mus musculus
15 Twist1  
Proximity Label-MS Mus musculus
16 Invs  
Affinity Capture-MS Mus musculus
17 Sstr3  
Proximity Label-MS Mus musculus
18 Eed  
Affinity Capture-MS Mus musculus
19 Cpt1b  
Cross-Linking-MS (XL-MS) Mus musculus
20 Atg16l1  
Affinity Capture-MS Mus musculus
21 Fancd2  
Affinity Capture-MS Mus musculus
22 Abhd4  
Co-fractionation Mus musculus
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